Nat8l N-acetyltransferase 8-like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nat8lprovided by RGD
Official Full Name: N-acetyltransferase 8-likeprovided by RGD
Primary source: RGD:1305719
See related: EnsemblRapid:ENSRNOG00000049351 AllianceGenome:RGD:1305719
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1305719
Summary: Enables aspartate N-acetyltransferase activity. Predicted to be involved in acetate metabolic process; aspartate metabolic process; and positive regulation of dopamine uptake involved in synaptic transmission. Located in mitochondrion. Orthologous to human NAT8L (N-acetyltransferase 8 like). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 187.3), Adrenal (RPKM 46.2) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (80980629..80987264, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (76756077..76762712, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (82041616..82048251, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The decrease in N-acetylaspartate following severe traumatic brain injury was characterized by profound mitochondrial malfunctioning, dramatic repression of Nat8l gene and concomitant increase in the ASPA gene and protein levels.
Title: The molecular mechanisms affecting N-acetylaspartate homeostasis following experimental graded traumatic brain injury.
Asp-NAT/NAT8L and NAA immunoreactivities correlate very well in rat brain, with primary localization in neurons, including cortical pyramidal neurons and granule cells of the hippocampus.
Title: Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: implications for specialized acetyl coenzyme A metabolism in the CNS.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aspartate N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aspartate N-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables aspartate N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acetate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in aspartate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dopamine uptake involved in synaptic transmission	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: N-acetylaspartate synthetase

Names: N-acetyltransferase 8-like protein; NAA synthetase

NP_001178610.1

EC 2.3.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.