Zfp12 zinc finger protein 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Zfp12provided by RGD
Full Name: zinc finger protein 12provided by RGD
Primary source: RGD:1564396
See related: EnsemblRapid:ENSRNOG00000006958 AllianceGenome:RGD:1564396
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1564396
Summary: Predicted to enable sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be located in centrosome and nucleoplasm. Orthologous to human ZNF12 (zinc finger protein 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 50.0), Thymus (RPKM 39.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12p11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (16430546..16446063, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (11316971..11330498, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (13370504..13384034, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH141581 (e-PCR)
- UniSTS:223575

ha1563 (e-PCR)
- UniSTS:515450

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427192.1 → NP_001414121.1 zinc finger protein 12

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A6K1M0

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

16430546..16446063 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_221917.11 → XP_221917.5 zinc finger protein 12 isoform X1

See identical proteins and their annotated locations for XP_221917.5

UniProtKB/TrEMBL

A6K1M1

Related

ENSRNOP00000110907.1, ENSRNOT00000134116.1

Conserved Domains (6) summary

smart00349
Location:8 → 68

KRAB; krueppel associated box

COG5048
Location:300 → 676

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:320 → 340

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:402 → 424

zf-C2H2; Zinc finger, C2H2 type

pfam01352
Location:8 → 47

KRAB; KRAB box

pfam13465
Location:472 → 497

zf-H2C2_2; Zinc-finger double domain
XM_063271141.1 → XP_063127211.1 zinc finger protein 12 isoform X2
XM_063271140.1 → XP_063127210.1 zinc finger protein 12 isoform X2