Elmo2 engulfment and cell motility 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Elmo2provided by RGD
Full Name: engulfment and cell motility 2provided by RGD
Primary source: RGD:1305784
See related: EnsemblRapid:ENSRNOG00000018747 AllianceGenome:RGD:1305784
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in actin filament organization and cell chemotaxis. Predicted to be located in cytosol and membrane. Orthologous to human ELMO2 (engulfment and cell motility 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 140.6), Brain (RPKM 139.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (174442965..174716723, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (154023661..154061259, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (161812474..161850006, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AA859271 (e-PCR)
- UniSTS:261129

BF389765 (e-PCR)
- UniSTS:245530

RH127321 (e-PCR)
- UniSTS:210631

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in cell motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in phagocytosis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: engulfment and cell motility protein 2

Names: engulfment and cell motility 2, ced-12 homolog; engulfment and cell motility protein 2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134955.4 → NP_001128427.1 engulfment and cell motility protein 2 isoform 1

See identical proteins and their annotated locations for NP_001128427.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6G6K9, A6JXF0, G3V982

Related

ENSRNOP00000039023.3, ENSRNOT00000049262.6

Conserved Domains (3) summary

cd13359
Location:551 → 680

PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain

pfam04727
Location:307 → 486

ELMO_CED12; ELMO/CED-12 family

pfam11841
Location:116 → 283

DUF3361; Domain of unknown function (DUF3361)
NM_001434383.1 → NP_001421312.1 engulfment and cell motility protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6G6K9, A6JXE9

RNA

NR_197778.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

174442965..174716723 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063284221.1 → XP_063140291.1 engulfment and cell motility protein 2 isoform X2
XM_006235599.5 → XP_006235661.1 engulfment and cell motility protein 2 isoform X1

Conserved Domains (3) summary

cd13359
Location:539 → 668

PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain

pfam04727
Location:297 → 469

ELMO_CED12; ELMO/CED-12 family

pfam11841
Location:115 → 271

DUF3361; Domain of unknown function (DUF3361)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001013208.1: Suppressed sequence

Description

NM_001013208.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.