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    Tmem91 transmembrane protein 91 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100359879, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem91provided by RGD
    Official Full Name
    transmembrane protein 91provided by RGD
    Primary source
    RGD:2323264
    See related
    EnsemblRapid:ENSRNOG00000068180 AllianceGenome:RGD:2323264
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be active in intracellular membrane-bounded organelle and membrane. Orthologous to human TMEM91 (transmembrane protein 91). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 24.4), Adrenal (RPKM 7.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem91 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (90307264..90314796, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (81179483..81187005, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (82463824..82471310, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 Neighboring gene branched chain keto acid dehydrogenase E1 subunit alpha Neighboring gene exosome component 5 Neighboring gene uncharacterized LOC134482996 Neighboring gene B9 domain containing 2 Neighboring gene transforming growth factor, beta 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 91

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432689.1 → NP_001419618.1  transmembrane protein 91 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    2. NM_001432690.1 → NP_001419619.1  transmembrane protein 91 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    3. NM_001432691.1 → NP_001419620.1  transmembrane protein 91 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    4. NM_001432692.1 → NP_001419621.1  transmembrane protein 91 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6GKN9, A6J980, A6J982

    5. NM_001432693.1 → NP_001419622.1  transmembrane protein 91 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6GKN9, A6J980, A6J982

    6. NM_001432694.1 → NP_001419623.1  transmembrane protein 91 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6GKN9, A6J980, A6J982

    7. NM_001432695.1 → NP_001419624.1  transmembrane protein 91 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6J982

    8. NM_001432696.1 → NP_001419625.1  transmembrane protein 91 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6J982

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      90307264..90314796 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093613.2 → XP_038949541.1  transmembrane protein 91 isoform X6

      Conserved Domains (1) summary
      pfam04505
      Location:92 → 158
      CD225; Interferon-induced transmembrane protein

    2. XM_002728716.7 → XP_002728762.3  transmembrane protein 91 isoform X1

      See identical proteins and their annotated locations for XP_002728762.3

      Conserved Domains (1) summary
      pfam04505
      Location:190 → 255
      CD225; Interferon-induced transmembrane protein

    3. XM_039093602.2 → XP_038949530.1  transmembrane protein 91 isoform X3

      Conserved Domains (1) summary
      pfam04505
      Location:190 → 218
      CD225; Interferon-induced transmembrane protein

    4. XM_006228522.5 → XP_006228584.3  transmembrane protein 91 isoform X2

      Related
      ENSRNOP00000111140.1, ENSRNOT00000167000.1

    5. XM_006228525.3 → XP_006228587.1  transmembrane protein 91 isoform X6

      UniProtKB/TrEMBL
      D4A8D1
      Conserved Domains (1) summary
      pfam04505
      Location:92 → 158
      CD225; Interferon-induced transmembrane protein

    6. XM_006228526.4 → XP_006228588.1  transmembrane protein 91 isoform X6

      UniProtKB/TrEMBL
      D4A8D1
      Related
      ENSRNOP00000100779.1, ENSRNOT00000121624.1
      Conserved Domains (1) summary
      pfam04505
      Location:92 → 158
      CD225; Interferon-induced transmembrane protein

    7. XM_039093604.2 → XP_038949532.1  transmembrane protein 91 isoform X4

      Conserved Domains (1) summary
      pfam04505
      Location:106 → 172
      CD225; Interferon-induced transmembrane protein

    8. XM_063277675.1 → XP_063133745.1  transmembrane protein 91 isoform X7

      UniProtKB/TrEMBL
      A6J982

    9. XM_039093621.2 → XP_038949549.1  transmembrane protein 91 isoform X8

      Conserved Domains (1) summary
      pfam04505
      Location:62 → 128
      CD225; Interferon-induced transmembrane protein

    10. XM_063277674.1 → XP_063133744.1  transmembrane protein 91 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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