Mepe matrix extracellular phosphoglycoprotein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mepeprovided by RGD
Official Full Name: matrix extracellular phosphoglycoproteinprovided by RGD
Primary source: RGD:71036
See related: AllianceGenome:RGD:71036
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: OF45
Summary: Predicted to enable extracellular matrix protein binding activity. Involved in regulation of bone remodeling. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Orthologous to human MEPE (matrix extracellular phosphoglycoprotein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 8.9), Adrenal (RPKM 1.0) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (5725308..5736858, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (5420634..5432186, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (6782011..6793561, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Four genes are expressed significantly higher in basal bone than in alveolar bone: SOST, E-11, DMP-1, and MEPE. Three of the proteins (SOST, MEPE, and DMP-1) are associated with mature osteocytes, indicating that basal bone has more mature osteocyte phenotypes because the immature osteocyte converts to a mature osteocyte as a result of bone mineralization.
Title: Inherent physical characteristics and gene expression differences between alveolar and basal bones.
expression of matrix extracellular phosphoglycoprotein (MEPE) in cortical bone of the rat tibia after mechanical loading
Title: Increased expression of matrix extracellular phosphoglycoprotein (MEPE) in cortical bone of the rat tibia after mechanical loading: identification by oligonucleotide microarray.
MEPE expression is bone cell-specific and induced by the BMP-2 signaling pathway
Title: Molecular regulation of matrix extracellular phosphoglycoprotein expression by bone morphogenetic protein-2.
MEPE is a candidate phosphatonin involved in phosphate homeostasis, acting in both the kidney and the gastrointestinal tract
Title: Matrix extracellular phosphoglycoprotein inhibits phosphate transport.

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General gene information

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Markers

BE097139 (e-PCR)
- UniSTS:244606

BE107579 (e-PCR)
- UniSTS:246925

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables extracellular matrix protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biomineral tissue development	IBA Inferred from Biological aspect of Ancestor more info
involved_in biomineral tissue development	IEA Inferred from Electronic Annotation more info
acts_upstream_of bone mineralization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in regulation of bone remodeling	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: matrix extracellular phosphoglycoprotein

Names: matrix extracellular phosphoglycoprotein with ASARM motif (bone); osteoblast/osteocyte factor 45; osteoregulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.