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    Pxylp1 2-phosphoxylose phosphatase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315939, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pxylp1provided by RGD
    Official Full Name
    2-phosphoxylose phosphatase 1provided by RGD
    Primary source
    RGD:1359617
    See related
    EnsemblRapid:ENSRNOG00000012480 AllianceGenome:RGD:1359617
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Acpl2
    Summary
    Predicted to enable phosphatase activity. Predicted to be involved in chondroitin sulfate proteoglycan biosynthetic process; glycosaminoglycan biosynthetic process; and positive regulation of heparan sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Orthologous to human PXYLP1 (2-phosphoxylose phosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 65.1), Kidney (RPKM 55.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pxylp1 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (106299303..106364603, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (97419766..97485163, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (104724728..104790639, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 38 Neighboring gene uncharacterized LOC100909637 Neighboring gene uncharacterized LOC134480088 Neighboring gene uncharacterized LOC120094379 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycans. Koike T, et al. J Biol Chem, 2014 Mar 7. PMID 24425863, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94167

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chondroitin sulfate proteoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chondroitin sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chondroitin sulfate proteoglycan biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycosaminoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycosaminoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosaminoglycan biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of heparan sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of heparan sulfate proteoglycan biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    2-phosphoxylose phosphatase 1
    Names
    acid phosphatase-like 2
    acid phosphatase-like protein 2
    NP_001007711.1
    XP_006243653.1
    XP_006243654.1
    XP_017451167.1
    XP_063121655.1
    XP_063121656.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007710.1 → NP_001007711.1  2-phosphoxylose phosphatase 1

      See identical proteins and their annotated locations for NP_001007711.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081981
      UniProtKB/Swiss-Prot
      Q66H78
      UniProtKB/TrEMBL
      A0A8I6AKD7
      Related
      ENSRNOP00000017085.4, ENSRNOT00000017085.6
      Conserved Domains (1) summary
      cl11399
      Location:87 → 424
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      106299303..106364603 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243591.5 → XP_006243653.1  2-phosphoxylose phosphatase 1 isoform X1

      See identical proteins and their annotated locations for XP_006243653.1

      UniProtKB/Swiss-Prot
      Q66H78
      UniProtKB/TrEMBL
      A0A8I6AKD7
      Conserved Domains (1) summary
      cl11399
      Location:87 → 424
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

    2. XM_063265585.1 → XP_063121655.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q66H78
      UniProtKB/TrEMBL
      A0A8I6AKD7

    3. XM_063265586.1 → XP_063121656.1  2-phosphoxylose phosphatase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q66H78
      UniProtKB/TrEMBL
      A0A8I6AKD7

    4. XM_006243592.4 → XP_006243654.1  2-phosphoxylose phosphatase 1 isoform X1

      See identical proteins and their annotated locations for XP_006243654.1

      UniProtKB/Swiss-Prot
      Q66H78
      UniProtKB/TrEMBL
      A0A8I6AKD7
      Conserved Domains (1) summary
      cl11399
      Location:87 → 424
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

    5. XM_017595678.3 → XP_017451167.1  2-phosphoxylose phosphatase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AKD7
      Related
      ENSRNOP00000106723.1, ENSRNOT00000124727.1

    RNA

    1. XR_010053981.1 RNA Sequence

    2. XR_010053979.1 RNA Sequence

    3. XR_010053980.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66H78.1 GenPept UniProtKB/Swiss-Prot:Q66H78

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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