N4bp2l2 NEDD4 binding protein 2-like 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: N4bp2l2provided by RGD
Full Name: NEDD4 binding protein 2-like 2provided by RGD
Primary source: RGD:1359603
See related: EnsemblRapid:ENSRNOG00000001108 AllianceGenome:RGD:1359603
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable enzyme binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of hematopoietic stem cell differentiation; negative regulation of transcription by RNA polymerase II; and positive regulation of hematopoietic stem cell proliferation. Predicted to act upstream of or within blastocyst development. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Orthologous to human N4BP2L2 (NEDD4 binding protein 2 like 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 267.5), Spleen (RPKM 208.8) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12p12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (4972967..5038027, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (137342..200292, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (627128..650604, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH130841 (e-PCR)
- UniSTS:214125

RH131153 (e-PCR)
- UniSTS:214436

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blastocyst development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hematopoietic stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of hematopoietic stem cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of transcription repressor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NEDD4-binding protein 2-like 2

Names: phosphonoformate immuno-associated protein 5 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005533.2 → NP_001005533.1 NEDD4-binding protein 2-like 2 isoform 2

See identical proteins and their annotated locations for NP_001005533.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

Q66H65

UniProtKB/TrEMBL

A0A8I5ZLI8

Related

ENSRNOP00000078717.2, ENSRNOT00000116179.2

Conserved Domains (1) summary

pfam13671
Location:395 → 528

AAA_33; AAA domain
NM_001400958.1 → NP_001387887.1 NEDD4-binding protein 2-like 2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A0A8I6AIC7

Related

ENSRNOP00000081414.2, ENSRNOT00000111844.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

4972967..5038027 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063271111.1 → XP_063127181.1 NEDD4-binding protein 2-like 2 isoform X3

UniProtKB/TrEMBL

A0A8I6AIC7

Related

ENSRNOP00000088209.2, ENSRNOT00000118063.2
XM_063271110.1 → XP_063127180.1 NEDD4-binding protein 2-like 2 isoform X2

UniProtKB/TrEMBL

A0A8I6AIC7
XM_039089151.2 → XP_038945079.1 NEDD4-binding protein 2-like 2 isoform X1

UniProtKB/TrEMBL

A0A8I6AIC7

Conserved Domains (1) summary

pfam13671
Location:469 → 602

AAA_33; AAA domain
XM_063271114.1 → XP_063127184.1 NEDD4-binding protein 2-like 2 isoform X8
XM_006248735.4 → XP_006248797.2 NEDD4-binding protein 2-like 2 isoform X4

UniProtKB/TrEMBL

A0A8I5ZSH6

Conserved Domains (1) summary

pfam13671
Location:469 → 602

AAA_33; AAA domain
XM_063271113.1 → XP_063127183.1 NEDD4-binding protein 2-like 2 isoform X6

UniProtKB/TrEMBL

A6KSV3
XM_063271112.1 → XP_063127182.1 NEDD4-binding protein 2-like 2 isoform X6

UniProtKB/TrEMBL

A6KSV3
XM_039089150.2 → XP_038945078.1 NEDD4-binding protein 2-like 2 isoform X5

UniProtKB/TrEMBL

A6KSV3

Conserved Domains (1) summary

pfam13671
Location:469 → 556

AAA_33; AAA domain
XM_039089152.2 → XP_038945080.2 NEDD4-binding protein 2-like 2 isoform X7