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    Il22ra2 interleukin 22 receptor subunit alpha 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 444986, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Il22ra2provided by RGD
    Official Full Name
    interleukin 22 receptor subunit alpha 2provided by RGD
    Primary source
    RGD:1303169
    See related
    EnsemblRapid:ENSRNOG00000012259 AllianceGenome:RGD:1303169
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Crf2-s1
    Summary
    Predicted to enable interleukin-22 binding activity and interleukin-22 receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to act upstream of or within negative regulation of inflammatory response and regulation of tyrosine phosphorylation of STAT protein. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Orthologous to human IL22RA2 (interleukin 22 receptor subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 71.9), Thymus (RPKM 37.6) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Il22ra2 in Genome Data Viewer
    Location:
    1p12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (16172238..16228009)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (14353736..14377844)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (15084136..15107423)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484957 Neighboring gene SUB1 regulator of transcription, pseudogene 3 Neighboring gene uncharacterized LOC134482580 Neighboring gene interferon gamma receptor 1 Neighboring gene uncharacterized LOC120098799 Neighboring gene interleukin 20 receptor subunit alpha Neighboring gene uncharacterized LOC120097186 Neighboring gene 60S ribosomal protein L27a-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. IL-22RA2 associates with multiple sclerosis and macrophage effector mechanisms in experimental neuroinflammation. Beyeen AD, et al. J Immunol, 2010 Dec 1. PMID 21041731
    2. Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity. Kotenko SV, et al. J Immunol, 2001 Jun 15. PMID 11390454
    3. Limited Presence of IL-22 Binding Protein, a Natural IL-22 Inhibitor, Strengthens Psoriatic Skin Inflammation. Martin JC, et al. J Immunol, 2017 May 1. PMID 28356382
    4. Cloning of murine IL-22 receptor alpha 2 and comparison with its human counterpart. Weiss B, et al. Genes Immun, 2004 Aug. PMID 15201862
    5. Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22. Dumoutier L, et al. J Immunol, 2001 Jun 15. PMID 11390453

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our results demonstrate a pathogenic role of IL-22BP in three species with a potential mechanism of action involving T cell polarization
      Title: IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis.
    2. this study shows that rats with genetic IL-22BP deficiency (Il22ra2-/-) display exacerbated psoriasis that is associated with enhanced expression of IL-22-inducible antimicrobial peptides
      Title: Limited Presence of IL-22 Binding Protein, a Natural IL-22 Inhibitor, Strengthens Psoriatic Skin Inflammation.
    3. IL-22BP is produced by eosinophils in the gut and blocks IL-22 protective actions in colitis.
      Title: IL-22BP is produced by eosinophils in human gut and blocks IL-22 protective actions during colitis.
    4. Through a combined approach including genetic and immunological investigation in an animal model and large-scale association studies of patients with multiple sclerosis (MS), IL-22RA2 is established as an MS risk gene.
      Title: IL-22RA2 associates with multiple sclerosis and macrophage effector mechanisms in experimental neuroinflammation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-22 binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables interleukin-22 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables interleukin-22 receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables interleukin-22 receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interleukin-22-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-22 receptor subunit alpha-2
    Names
    IL-22 receptor subunit alpha-2
    IL-22BP
    IL-22R-alpha-2
    IL-22RA2
    IL22BP
    cytokine receptor family II soluble 1
    cytokine receptor family type 2, soluble 1
    interleukin 22 receptor, alpha 2
    interleukin-22-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003404.2 → NP_001003404.1  interleukin-22 receptor subunit alpha-2 precursor

      See identical proteins and their annotated locations for NP_001003404.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q7TNI4
      UniProtKB/TrEMBL
      A0A8L2UIY2, A6JPB3
      Related
      ENSRNOP00000016354.4, ENSRNOT00000016354.5
      Conserved Domains (2) summary
      pfam01108
      Location:5 → 112
      Tissue_fac; Tissue factor
      pfam09294
      Location:124 → 229
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      16172238..16228009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270279.1 → XP_063126349.1  interleukin-22 receptor subunit alpha-2 isoform X2

    2. XM_063270284.1 → XP_063126354.1  interleukin-22 receptor subunit alpha-2 isoform X3

    3. XM_063270290.1 → XP_063126360.1  interleukin-22 receptor subunit alpha-2 isoform X4

    4. XM_063270285.1 → XP_063126355.1  interleukin-22 receptor subunit alpha-2 isoform X4

    5. XM_063270275.1 → XP_063126345.1  interleukin-22 receptor subunit alpha-2 isoform X1

    6. XM_063270277.1 → XP_063126347.1  interleukin-22 receptor subunit alpha-2 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TNI4.1 GenPept UniProtKB/Swiss-Prot:Q7TNI4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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