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    Dusp18 dual specificity phosphatase 18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305477, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dusp18provided by RGD
    Official Full Name
    dual specificity phosphatase 18provided by RGD
    Primary source
    RGD:1306929
    See related
    EnsemblRapid:ENSRNOG00000024945 AllianceGenome:RGD:1306929
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in peptidyl-threonine dephosphorylation and peptidyl-tyrosine dephosphorylation. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human DUSP18 (dual specificity phosphatase 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 49.0), Testes (RPKM 33.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dusp18 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (83013850..83035168)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (78790183..78811576)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (84150484..84169645)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene transcription initiation factor IIA subunit 2-like Neighboring gene similar to human chromosome 5 open reading frame 52 Neighboring gene solute carrier family 35, member E4 Neighboring gene transcobalamin 2 Neighboring gene pescadillo ribosomal biogenesis factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of a novel dual-specificity phosphatase18 gene from human fetal brain. Wu Q, et al. Biochim Biophys Acta, 2003 Feb 20. PMID 12591617
    2. Identification and characterization of two novel low-molecular-weight dual specificity phosphatases. Hood KL, et al. Biochem Biophys Res Commun, 2002 Nov 8. PMID 12408986
    3. Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane. Rardin MJ, et al. J Biol Chem, 2008 May 30. PMID 18385140, Free PMC Article
    4. The family-wide structure and function of human dual-specificity protein phosphatases. Jeong DG, et al. Acta Crystallogr D Biol Crystallogr, 2014 Feb. PMID 24531476
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane
      Title: Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peptidyl-threonine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-threonine dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peptidyl-tyrosine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-tyrosine dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity protein phosphatase 18
    NP_001013146.2
    XP_006251361.1
    XP_063129275.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013128.2 → NP_001013146.2  dual specificity protein phosphatase 18

      See identical proteins and their annotated locations for NP_001013146.2

      Status: VALIDATED

      Source sequence(s)
      BC079285, JAXUCZ010000014
      UniProtKB/Swiss-Prot
      Q6AXW7
      UniProtKB/TrEMBL
      F1LN58
      Related
      ENSRNOP00000005516.2, ENSRNOT00000005516.7
      Conserved Domains (1) summary
      cd14573
      Location:19 → 176
      DUSP18_21; dual specificity protein phosphatases 18 and 21

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      83013850..83035168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251299.4 → XP_006251361.1  dual specificity protein phosphatase 18 isoform X1

      See identical proteins and their annotated locations for XP_006251361.1

      UniProtKB/Swiss-Prot
      Q6AXW7
      UniProtKB/TrEMBL
      F1LN58
      Conserved Domains (1) summary
      cd14573
      Location:19 → 176
      DUSP18_21; dual specificity protein phosphatases 18 and 21

    2. XM_063273205.1 → XP_063129275.1  dual specificity protein phosphatase 18 isoform X2

    RNA

    1. XR_005492971.2 RNA Sequence

    2. XR_005492970.2 RNA Sequence

    3. XR_359626.5 RNA Sequence

      Related
      ENSRNOT00000099804.2

    4. XR_005492972.2 RNA Sequence

    5. XR_005492973.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AXW7.1 GenPept UniProtKB/Swiss-Prot:Q6AXW7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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