Fignl1 fidgetin-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fignl1provided by RGD
Official Full Name: fidgetin-like 1provided by RGD
Primary source: RGD:1307112
See related: EnsemblRapid:ENSRNOG00000004440 AllianceGenome:RGD:1307112
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ATP hydrolysis activity; magnesium ion binding activity; and microtubule severing ATPase activity. Predicted to be involved in several processes, including cellular response to ionizing radiation; osteoblast proliferation; and regulation of double-strand break repair via homologous recombination. Predicted to act upstream of or within negative regulation of intrinsic apoptotic signaling pathway. Predicted to be located in nuclear chromosome and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to human FIGNL1 (fidgetin like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 39.2), Thymus (RPKM 30.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (90573090..90595342, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (86368670..86381728, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (91895902..91904474, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH142989 (e-PCR)
- UniSTS:232236

RH143134 (e-PCR)
- UniSTS:232381

UniSTS:236520 (e-PCR)
- UniSTS:236520

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables microtubule severing ATPase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ATP metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to ionizing radiation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ionizing radiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in male meiotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in male meiotic nuclear division	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in osteoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in osteoblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in regulation of double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear chromosome	ISO Inferred from Sequence Orthology more info
located_in nuclear chromosome	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: fidgetin-like protein 1

NP_001011913.1

EC 3.6.4.-

NP_001380737.1

EC 3.6.4.-

NP_001380738.1

EC 3.6.4.-

XP_006251539.1

EC 3.6.4.-

XP_063129023.1

EC 3.6.4.-

XP_063129024.1

EC 3.6.4.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011913.2 → NP_001011913.1 fidgetin-like protein 1

See identical proteins and their annotated locations for NP_001011913.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

Q6GX84

UniProtKB/TrEMBL

A6KJB2

Conserved Domains (3) summary

pfam09336
Location:634 → 674

Vps4_C; Vps4 C terminal oligomerization domain

pfam17862
Location:593 → 624

AAA_lid_3; AAA+ lid domain

cd19525
Location:383 → 568

RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)
NM_001393808.1 → NP_001380737.1 fidgetin-like protein 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 all encode the same protein.

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

Q6GX84

UniProtKB/TrEMBL

A6KJB2

Conserved Domains (3) summary

pfam09336
Location:634 → 674

Vps4_C; Vps4 C terminal oligomerization domain

pfam17862
Location:593 → 624

AAA_lid_3; AAA+ lid domain

cd19525
Location:383 → 568

RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)
NM_001393809.1 → NP_001380738.1 fidgetin-like protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

Q6GX84

UniProtKB/TrEMBL

A6KJB2

Related

ENSRNOP00000101365.1, ENSRNOT00000134653.1

Conserved Domains (3) summary

pfam09336
Location:634 → 674

Vps4_C; Vps4 C terminal oligomerization domain

pfam17862
Location:593 → 624

AAA_lid_3; AAA+ lid domain

cd19525
Location:383 → 568

RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

90573090..90595342 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272954.1 → XP_063129024.1 fidgetin-like protein 1 isoform X3
XM_006251477.5 → XP_006251539.1 fidgetin-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_006251539.1

UniProtKB/Swiss-Prot

Q6GX84

UniProtKB/TrEMBL

A6KJB2

Related

ENSRNOP00000078689.1, ENSRNOT00000107994.2

Conserved Domains (3) summary

pfam09336
Location:634 → 674

Vps4_C; Vps4 C terminal oligomerization domain

pfam17862
Location:593 → 624

AAA_lid_3; AAA+ lid domain

cd19525
Location:383 → 568

RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)
XM_063272953.1 → XP_063129023.1 fidgetin-like protein 1 isoform X2

Related

ENSRNOP00000005857.4, ENSRNOT00000005857.6