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    Proc protein C, inactivator of coagulation factors Va and VIIIa [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25268, updated on 9-Dec-2024

    Summary

    Official Symbol
    Procprovided by RGD
    Official Full Name
    protein C, inactivator of coagulation factors Va and VIIIaprovided by RGD
    Primary source
    RGD:3411
    See related
    EnsemblRapid:ENSRNOG00000014376 AllianceGenome:RGD:3411
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables identical protein binding activity and oligopeptidase activity. Involved in liver development; negative regulation of blood coagulation; and protein catabolic process. Located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; central retinal vein occlusion; placental abruption; thrombophilia (multiple); and toxic shock syndrome. Orthologous to human PROC (protein C, inactivator of coagulation factors Va and VIIIa). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 1373.6) See more
    Orthologs
    NEW
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    Genomic context

    See Proc in Genome Data Viewer
    Location:
    18p12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (24038596..24049061, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (23764367..23774816, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (24918402..24928822, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482980 Neighboring gene POTE ankyrin domain family, member F Neighboring gene interacts with SUPT6H, CTD assembly factor 1 Neighboring gene uncharacterized LOC134482924 Neighboring gene mitogen activated protein kinase kinase kinase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables oligopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in liver development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within liver development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of blood coagulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of blood coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of coagulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of coagulation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of coagulation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of establishment of endothelial barrier IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of establishment of endothelial barrier ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of circulating fibrinogen levels ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    vitamin K-dependent protein C
    Names
    anticoagulant protein C
    autoprothrombin IIA
    blood coagulation factor XIV
    NP_036935.1
    XP_006254589.1
    XP_008770240.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012803.1NP_036935.1  vitamin K-dependent protein C precursor

      See identical proteins and their annotated locations for NP_036935.1

      Status: PROVISIONAL

      Source sequence(s)
      X64336
      UniProtKB/Swiss-Prot
      P31394
      UniProtKB/TrEMBL
      A6J2Q1
      Related
      ENSRNOP00000100621.1, ENSRNOT00000124587.1
      Conserved Domains (5) summary
      smart00020
      Location:212445
      Tryp_SPc; Trypsin-like serine protease
      smart00069
      Location:2686
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:87131
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00190
      Location:213447
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam14670
      Location:139174
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      24038596..24049061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254527.4XP_006254589.1  vitamin K-dependent protein C isoform X2

      See identical proteins and their annotated locations for XP_006254589.1

      UniProtKB/TrEMBL
      A6J2Q1, Q68FY8
      Related
      ENSRNOP00000019596.5, ENSRNOT00000019596.6
      Conserved Domains (4) summary
      smart00069
      Location:2686
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:87131
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00190
      Location:213447
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam14670
      Location:139174
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    2. XM_008772018.4XP_008770240.3  vitamin K-dependent protein C isoform X1

      UniProtKB/TrEMBL
      A6J2Q1, F7FMY6
      Conserved Domains (4) summary
      smart00069
      Location:65125
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:126170
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00190
      Location:252486
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam14670
      Location:178213
      FXa_inhibition; Coagulation Factor Xa inhibitory site