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    Map2k1 mitogen activated protein kinase kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170851, updated on 27-Dec-2024

    Summary

    Official Symbol
    Map2k1provided by RGD
    Official Full Name
    mitogen activated protein kinase kinase 1provided by RGD
    Primary source
    RGD:70495
    See related
    EnsemblRapid:ENSRNOG00000010176 AllianceGenome:RGD:70495
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mek1
    Summary
    Enables ATP binding activity; MAP kinase kinase activity; and enzyme binding activity. Involved in several processes, including positive regulation of metabolic process; regulation of intracellular signal transduction; and regulation of muscle contraction. Acts upstream of or within positive regulation of Ras protein signal transduction. Located in several cellular components, including dendrite cytoplasm; perikaryon; and perinuclear region of cytoplasm. Is active in glutamatergic synapse and postsynaptic density. Used to study cataract and prostate adenocarcinoma. Human ortholog(s) of this gene implicated in carcinoma (multiple); cardiofaciocutaneous syndrome 3; high grade glioma; and melorheostosis. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 508.0), Muscle (RPKM 301.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Map2k1 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (73578747..73650184, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (64683449..64754900, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (69134218..69722573, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 18C Neighboring gene ribosomal protein L4 Neighboring gene small nuclear RNA activating complex, polypeptide 5 Neighboring gene uncharacterized LOC134480193 Neighboring gene transfer RNA serine (anticodon AGA) 48 Neighboring gene timeless interacting protein Neighboring gene small Cajal body-specific RNA 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 28
    Function Evidence Code Pubs
    enables ATP binding PubMed 
    enables ATP binding  
    enables JUN kinase kinase activity  
    enables MAP kinase kinase activity  
    enables MAP kinase kinase activity PubMed 
    enables MAP kinase kinase activity  
    enables MAP kinase kinase activity  
    enables MAP kinase kinase activity PubMed 
    enables MAP-kinase scaffold activity  
    enables MAP-kinase scaffold activity  
    enables histone H2AXY142 kinase activity  
    enables histone H3Y41 kinase activity  
    enables mitogen-activated protein kinase kinase kinase binding PubMed 
    enables mitogen-activated protein kinase kinase kinase binding PubMed 
    enables protein binding PubMed 
    enables protein kinase activator activity  
    enables protein kinase binding PubMed 
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activator activity  
    enables protein serine/threonine kinase activator activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine/tyrosine kinase activity PubMed 
    enables protein tyrosine kinase activity  
    enables protein-containing complex binding PubMed 
    enables scaffold protein binding  
    enables scaffold protein binding  
    enables small GTPase binding PubMed 
    Items 1 - 25 of 28
    Items 1 - 25 of 104
    Process Evidence Code Pubs
    involved_in Bergmann glial cell differentiation  
    acts_upstream_of_or_within Bergmann glial cell differentiation  
    involved_in ERBB2-ERBB3 signaling pathway  
    involved_in ERBB2-ERBB3 signaling pathway  
    involved_in ERK1 and ERK2 cascade  
    acts_upstream_of_or_within ERK1 and ERK2 cascade  
    involved_in Golgi inheritance PubMed 
    involved_in JNK cascade  
    involved_in MAPK cascade  
    involved_in MAPK cascade  
    involved_in MAPK cascade  
    involved_in Schwann cell development  
    involved_in Schwann cell development  
    involved_in cell motility  
    acts_upstream_of_or_within cell motility  
    involved_in cellular senescence  
    involved_in cellular senescence  
    involved_in cerebellar cortex formation  
    acts_upstream_of_or_within cerebellar cortex formation  
    involved_in chromatin remodeling  
    involved_in endodermal cell differentiation  
    acts_upstream_of endodermal cell differentiation  
    involved_in epithelial cell proliferation involved in lung morphogenesis  
    acts_upstream_of_or_within epithelial cell proliferation involved in lung morphogenesis  
    involved_in face development  
    acts_upstream_of_or_within face development  
    involved_in heart development  
    acts_upstream_of_or_within heart development  
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in intracellular signal transduction PubMed 
    involved_in keratinocyte differentiation  
    acts_upstream_of_or_within keratinocyte differentiation  
    involved_in labyrinthine layer development  
    acts_upstream_of_or_within labyrinthine layer development  
    acts_upstream_of_or_within lung morphogenesis  
    involved_in melanosome transport PubMed 
    involved_in myelination  
    involved_in myelination  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of gene expression PubMed 
    involved_in negative regulation of homotypic cell-cell adhesion PubMed 
    involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway PubMed 
    involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway PubMed 
    involved_in neuron differentiation  
    involved_in neuron differentiation  
    involved_in neuron differentiation PubMed 
    acts_upstream_of_or_within neuron differentiation  
    involved_in neuron projection morphogenesis PubMed 
    involved_in placenta blood vessel development  
    acts_upstream_of_or_within placenta blood vessel development  
    involved_in positive regulation of ATP biosynthetic process PubMed 
    involved_in positive regulation of ATP biosynthetic process PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of GTPase activity PubMed 
    involved_in positive regulation of MAPK cascade PubMed 
    acts_upstream_of_or_within positive regulation of MAPK cascade  
    acts_upstream_of_or_within positive regulation of Ras protein signal transduction PubMed 
    involved_in positive regulation of autophagy PubMed 
    involved_in positive regulation of axonogenesis  
    acts_upstream_of_or_within positive regulation of axonogenesis  
    involved_in positive regulation of cell migration PubMed 
    involved_in positive regulation of endodermal cell differentiation  
    acts_upstream_of_or_within positive regulation of endodermal cell differentiation  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of gene expression  
    involved_in positive regulation of muscle contraction PubMed 
    involved_in positive regulation of muscle contraction PubMed 
    involved_in positive regulation of protein serine/threonine kinase activity  
    involved_in positive regulation of transcription elongation by RNA polymerase II PubMed 
    involved_in protein phosphorylation PubMed 
    acts_upstream_of_or_within protein phosphorylation  
    involved_in protein phosphorylation PubMed 
    involved_in regulation of ERK1 and ERK2 cascade PubMed 
    involved_in regulation of Golgi inheritance  
    involved_in regulation of Golgi inheritance PubMed 
    involved_in regulation of axon regeneration  
    acts_upstream_of_or_within regulation of axon regeneration  
    involved_in regulation of early endosome to late endosome transport  
    involved_in regulation of early endosome to late endosome transport PubMed 
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane PubMed 
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane PubMed 
    involved_in regulation of stress-activated MAPK cascade  
    involved_in regulation of stress-activated MAPK cascade PubMed 
    involved_in regulation of vascular associated smooth muscle contraction PubMed 
    involved_in response to axon injury PubMed 
    involved_in response to glucocorticoid PubMed 
    involved_in response to oxidative stress PubMed 
    involved_in thymus development  
    acts_upstream_of_or_within thymus development  
    involved_in thyroid gland development  
    acts_upstream_of_or_within thyroid gland development  
    involved_in trachea formation  
    acts_upstream_of_or_within trachea formation  
    involved_in triglyceride homeostasis PubMed 
    involved_in type B pancreatic cell proliferation  
    acts_upstream_of_positive_effect type B pancreatic cell proliferation  
    involved_in vesicle transport along microtubule PubMed 
    Items 1 - 25 of 104
    Items 1 - 20 of 30
    Component Evidence Code Pubs
    located_in Golgi apparatus PubMed 
    located_in axon PubMed 
    located_in cell cortex PubMed 
    located_in centrosome  
    located_in cytosol  
    located_in cytosol  
    located_in cytosol PubMed 
    located_in dendrite PubMed 
    located_in dendrite cytoplasm PubMed 
    located_in early endosome  
    located_in early endosome PubMed 
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in focal adhesion  
    located_in focal adhesion PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in late endosome  
    located_in late endosome PubMed 
    located_in membrane  
    located_in microtubule PubMed 
    located_in mitochondrion  
    located_in mitochondrion PubMed 
    located_in nucleus  
    located_in nucleus PubMed 
    located_in perikaryon PubMed 
    located_in perinuclear region of cytoplasm PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynaptic density PubMed 
    Items 1 - 20 of 30

    General protein information

    Preferred Names
    dual specificity mitogen-activated protein kinase kinase 1
    Names
    ERK activator kinase 1
    MAP kinase kinase 1
    MAP kinase/Erk kinase 1
    MAPK/ERK kinase 1
    MAPKK 1
    NP_113831.1
    XP_038936667.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031643.4NP_113831.1  dual specificity mitogen-activated protein kinase kinase 1

      See identical proteins and their annotated locations for NP_113831.1

      Status: VALIDATED

      Source sequence(s)
      AI603089, BC089772
      UniProtKB/Swiss-Prot
      Q01986, Q5EBD5
      UniProtKB/TrEMBL
      A0A0H2UHI2, A6J5B8
      Related
      ENSRNOP00000084527.2, ENSRNOT00000120242.2
      Conserved Domains (1) summary
      cd06650
      Location:62380
      PKc_MEK1; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      73578747..73650184 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080739.2XP_038936667.1  dual specificity mitogen-activated protein kinase kinase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZT77, A0A8I6A1J3
      Related
      ENSRNOP00000086602.1, ENSRNOT00000102833.2
      Conserved Domains (1) summary
      cd06650
      Location:40358
      PKc_MEK1; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 1
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