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    Snx1 sorting nexin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84471, updated on 9-Dec-2024

    Summary

    Official Symbol
    Snx1provided by RGD
    Official Full Name
    sorting nexin 1provided by RGD
    Primary source
    RGD:68935
    See related
    EnsemblRapid:ENSRNOG00000017029 AllianceGenome:RGD:68935
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol binding activity; protein dimerization activity; and signaling receptor binding activity. Involved in endosomal transport and positive regulation of protein catabolic process. Located in early endosome. Orthologous to human SNX1 (sorting nexin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 243.7), Kidney (RPKM 224.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Snx1 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (75515780..75565487, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (66630086..66670418, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (71745687..71786182, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene casein kinase 1, gamma 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene sorting nexin 22 Neighboring gene peptidylprolyl isomerase B Neighboring gene cytosolic iron-sulfur assembly component 2A Neighboring gene death-associated protein kinase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • MGC105373

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables epidermal growth factor receptor binding  
    enables epidermal growth factor receptor binding  
    enables identical protein binding  
    enables insulin receptor binding  
    enables insulin receptor binding  
    enables leptin receptor binding  
    enables leptin receptor binding  
    enables phosphatidylinositol binding  
    enables phosphatidylinositol binding  
    enables phosphatidylinositol binding  
    enables phosphatidylinositol binding  
    enables protein binding PubMed 
    enables protein heterodimerization activity  
    enables protein heterodimerization activity  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables transferrin receptor binding  
    enables transferrin receptor binding  
    Process Evidence Code Pubs
    involved_in early endosome to Golgi transport  
    involved_in early endosome to Golgi transport  
    involved_in early endosome to Golgi transport  
    involved_in endosomal transport PubMed 
    involved_in intracellular protein transport  
    involved_in intracellular protein transport  
    involved_in lamellipodium morphogenesis  
    involved_in lamellipodium morphogenesis  
    involved_in lamellipodium morphogenesis  
    acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway  
    involved_in neuron projection development  
    involved_in positive regulation of protein catabolic process PubMed 
    involved_in receptor internalization  
    involved_in receptor internalization  
    involved_in receptor internalization  
    involved_in retrograde transport, endosome to Golgi  
    involved_in retrograde transport, endosome to Golgi  
    Items 1 - 20 of 29
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in cytoplasm  
    located_in cytosol  
    located_in dendritic spine  
    located_in early endosome PubMed 
    located_in early endosome  
    located_in early endosome membrane  
    located_in early endosome membrane  
    is_active_in endosome  
    located_in endosome  
    is_active_in endosome membrane  
    located_in endosome membrane  
    located_in endosome membrane  
    is_active_in extrinsic component of postsynaptic endosome membrane  
    located_in intracellular membrane-bounded organelle  
    located_in lamellipodium  
    located_in lysosome  
    located_in lysosome  
    located_in membrane  
    located_in perinuclear region of cytoplasm  
    located_in postsynaptic density  
    is_active_in postsynaptic density, intracellular component  
    located_in postsynaptic density, intracellular component  
    located_in presynapse  
    part_of protein-containing complex  
    part_of retromer complex  
    part_of retromer, tubulation complex  
    part_of retromer, tubulation complex  
    located_in vesicle  
    Items 1 - 20 of 29

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053411.1NP_445863.1  sorting nexin-1

      See identical proteins and their annotated locations for NP_445863.1

      Status: PROVISIONAL

      Source sequence(s)
      AF218916
      UniProtKB/Swiss-Prot
      Q56A25, Q99N27
      UniProtKB/TrEMBL
      A0A8L2QBU0, A6J5H5
      Related
      ENSRNOP00000088585.2, ENSRNOT00000099946.2
      Conserved Domains (3) summary
      cd07281
      Location:145268
      PX_SNX1; The phosphoinositide binding Phox Homology domain of Sorting Nexin 1
      cd07665
      Location:286519
      BAR_SNX1; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 1
      pfam03700
      Location:1190
      Sorting_nexin; Sorting nexin, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      75515780..75565487 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266236.1XP_063122306.1  sorting nexin-1 isoform X3

      UniProtKB/TrEMBL
      A0A8L2QBU0
    2. XM_006243317.5XP_006243379.1  sorting nexin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y518, A0A8L2QBU0
      Related
      ENSRNOP00000076840.1, ENSRNOT00000110848.2
      Conserved Domains (3) summary
      cd07281
      Location:97220
      PX_SNX1; The phosphoinositide binding Phox Homology domain of Sorting Nexin 1
      cd07665
      Location:238471
      BAR_SNX1; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 1
      pfam03700
      Location:481
      Sorting_nexin; Sorting nexin, N-terminal domain
    3. XM_063266235.1XP_063122305.1  sorting nexin-1 isoform X2

    RNA

    1. XR_010054037.1 RNA Sequence

    2. XR_010054038.1 RNA Sequence

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