Dnase1l3 deoxyribonuclease 1L3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dnase1l3provided by RGD
Official Full Name: deoxyribonuclease 1L3provided by RGD
Primary source: RGD:620669
See related: EnsemblRapid:ENSRNOG00000009291 AllianceGenome:RGD:620669
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables DNA binding activity and DNA endonuclease activity. Predicted to be involved in several processes, including apoptotic DNA fragmentation; neutrophil activation involved in immune response; and regulation of neutrophil mediated cytotoxicity. Predicted to be located in endoplasmic reticulum. Predicted to be active in nucleus. Orthologous to human DNASE1L3 (deoxyribonuclease 1L3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 1514.6), Thymus (RPKM 284.2) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 15p14

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (19351683..19378536)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (16922335..16948322)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (18710492..18736476)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DNase gamma is suggested to be involved in naturally occurring apoptosis in developing nervous systems
Title: Differential DNases are selectively used in neuronal apoptosis depending on the differentiation state.
DNase gamma plays an important role in Fas-independent apoptotic DNA fragmentation in hepatocytes.
Title: Expression of DNase gamma during Fas-independent apoptotic DNA fragmentation in rodent hepatocytes.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA endonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA nuclease activity	IEA Inferred from Electronic Annotation more info
enables deoxyribonuclease I activity	IBA Inferred from Biological aspect of Ancestor more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables endonuclease activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in DNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in DNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in apoptotic DNA fragmentation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within apoptotic DNA fragmentation	ISO Inferred from Sequence Orthology more info
involved_in apoptotic DNA fragmentation	ISO Inferred from Sequence Orthology more info
involved_in apoptotic DNA fragmentation	TAS Traceable Author Statement more info	PubMed
involved_in neutrophil activation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in neutrophil activation involved in immune response	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in programmed cell death involved in cell development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within programmed cell death involved in cell development	ISO Inferred from Sequence Orthology more info
involved_in regulation of acute inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of acute inflammatory response	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of neutrophil mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in regulation of neutrophil mediated cytotoxicity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: deoxyribonuclease gamma

Names: DNase I-like 3; DNase gamma; DNaseY; deoxyribonuclease 1-like 3; deoxyribonuclease I-like 3; deoxyribonuclease gamma-like

NP_446359.1

EC 3.1.21.-

XP_063129983.1

EC 3.1.21.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.