U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Sardh sarcosine dehydrogenase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114123, updated on 9-Dec-2024

    Summary

    Symbol
    Sardhprovided by RGD
    Full Name
    sarcosine dehydrogenaseprovided by RGD
    Primary source
    RGD:621125
    See related
    EnsemblRapid:ENSRNOG00000006916 AllianceGenome:RGD:621125
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables flavin adenine dinucleotide binding activity; folic acid binding activity; and sarcosine dehydrogenase activity. Involved in tetrahydrofolate interconversion. Located in mitochondrial matrix. Human ortholog(s) of this gene implicated in sarcosinemia. Orthologous to human SARDH (sarcosine dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 535.2), Kidney (RPKM 324.8) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Sardh in Genome Data Viewer
    Location:
    3p12
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (30908621..30973409, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (10510553..10575342, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (5737203..5802153, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486349 Neighboring gene dopamine beta-hydroxylase Neighboring gene uncharacterized LOC102548789 Neighboring gene vav guanine nucleotide exchange factor 2 Neighboring gene BRD3 opposite strand

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in mitochondrial matrix  
    located_in mitochondrial matrix PubMed 
    is_active_in mitochondrion  
    located_in mitochondrion  
    located_in mitochondrion  
    located_in mitochondrion  

    General protein information

    Preferred Names
    sarcosine dehydrogenase, mitochondrial
    NP_001409929.1
    NP_446116.2
    XP_006233793.1
    XP_006233795.1
    XP_038960018.1
    XP_063139062.1
    XP_063139063.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001423000.1NP_001409929.1  sarcosine dehydrogenase, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      O88499, Q64380
      UniProtKB/TrEMBL
      A6JTK8, F1LRY5
      Related
      ENSRNOP00000009555.6, ENSRNOT00000009555.9
    2. NM_001429649.1NP_001416578.1  sarcosine dehydrogenase, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      O88499, Q64380
      UniProtKB/TrEMBL
      A6JTK8, F1LRY5
    3. NM_001429650.1NP_001416579.1  sarcosine dehydrogenase, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      O88499, Q64380
      UniProtKB/TrEMBL
      A6JTK8, F1LRY5
    4. NM_053664.3NP_446116.2  sarcosine dehydrogenase, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      O88499, Q64380
      UniProtKB/TrEMBL
      A6JTK8, F1LRY5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      30908621..30973409 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233733.5XP_006233795.1  sarcosine dehydrogenase, mitochondrial isoform X1

      Conserved Domains (3) summary
      COG0404
      Location:480917
      GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
      COG0665
      Location:64448
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
      pfam16350
      Location:431486
      FAO_M; FAD dependent oxidoreductase central domain
    2. XM_006233731.5XP_006233793.1  sarcosine dehydrogenase, mitochondrial isoform X1

      Conserved Domains (3) summary
      COG0404
      Location:480917
      GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
      COG0665
      Location:64448
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
      pfam16350
      Location:431486
      FAO_M; FAD dependent oxidoreductase central domain
    3. XM_063282992.1XP_063139062.1  sarcosine dehydrogenase, mitochondrial isoform X2

    4. XM_039104090.2XP_038960018.1  sarcosine dehydrogenase, mitochondrial isoform X2

      Conserved Domains (3) summary
      COG0665
      Location:64448
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
      pfam16350
      Location:431486
      FAO_M; FAD dependent oxidoreductase central domain
      cl39066
      Location:480512
      GCV_T; Aminomethyltransferase folate-binding domain
    5. XM_063282993.1XP_063139063.1  sarcosine dehydrogenase, mitochondrial isoform X3

    External link. Please review our privacy policy.