Ddhd2 DDHD domain containing 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ddhd2provided by RGD
Official Full Name: DDHD domain containing 2provided by RGD
Primary source: RGD:1585818
See related: EnsemblRapid:ENSRNOG00000015501 AllianceGenome:RGD:1585818
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable phospholipase activity and triacylglycerol lipase activity. Predicted to act upstream of or within lipid droplet organization; positive regulation of mitochondrial fission; and triglyceride catabolic process. Predicted to be located in centriolar satellite and cytosol. Predicted to be active in COPII-coated ER to Golgi transport vesicle and membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 54. Orthologous to human DDHD2 (DDHD domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 207.0), Adrenal (RPKM 166.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.4

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (73022136..73051746)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (66319469..66349025)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (71090096..71120713)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results therefore support the idea that DDHD2 functions as a DG lipase in vivo and produces 2-AG.
Title: Enzymatic characterization of recombinant rat DDHD2: a soluble diacylglycerol lipase.
DG lipase activity in the soluble fraction of rat brain is derived from DDHD2. DDHD2 is distributed widely in the rat brain. Immunohistochemical analysis revealed that DDHD2 is expressed in hippocampal neurons, but not in glia.
Title: Protein purification and cloning of diacylglycerol lipase from rat brain.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phospholipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables triacylglycerol lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables triacylglycerol lipase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid droplet organization	ISO Inferred from Sequence Orthology more info
involved_in lipid droplet organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of mitochondrial fission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mitochondrial fission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within triglyceride catabolic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of visual learning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within visual learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in COPII-coated ER to Golgi transport vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phospholipase DDHD2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001318416.1 → NP_001305345.1 phospholipase DDHD2

Status: PROVISIONAL

Source sequence(s)

AB914679

UniProtKB/TrEMBL

A0A8I6AUM0, D3ZJ91

Conserved Domains (4) summary

smart00454
Location:386 → 445

SAM; Sterile alpha motif

pfam02825
Location:42 → 112

WWE; WWE domain

pfam02862
Location:487 → 687

DDHD; DDHD domain

cl15755
Location:379 → 447

SAM_superfamily; SAM (Sterile alpha motif )

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

73022136..73051746

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001059724.8 → XP_001059724.3 phospholipase DDHD2 isoform X1

See identical proteins and their annotated locations for XP_001059724.3

UniProtKB/TrEMBL

A0A8I6AUM0, D3ZJ91

Conserved Domains (4) summary

smart00454
Location:386 → 445

SAM; Sterile alpha motif

pfam02825
Location:42 → 112

WWE; WWE domain

pfam02862
Location:487 → 687

DDHD; DDHD domain

cl15755
Location:379 → 447

SAM_superfamily; SAM (Sterile alpha motif )
XM_006253339.5 → XP_006253401.1 phospholipase DDHD2 isoform X1

See identical proteins and their annotated locations for XP_006253401.1

UniProtKB/TrEMBL

A0A8I6AUM0, D3ZJ91

Related

ENSRNOP00000020832.8, ENSRNOT00000020832.10

Conserved Domains (4) summary

smart00454
Location:386 → 445

SAM; Sterile alpha motif

pfam02825
Location:42 → 112

WWE; WWE domain

pfam02862
Location:487 → 687

DDHD; DDHD domain

cl15755
Location:379 → 447

SAM_superfamily; SAM (Sterile alpha motif )
XM_063275720.1 → XP_063131790.1 phospholipase DDHD2 isoform X2

UniProtKB/TrEMBL

D3ZJ91

Related

ENSRNOP00000096096.2, ENSRNOT00000117689.2
XM_008771368.3 → XP_008769590.1 phospholipase DDHD2 isoform X2

See identical proteins and their annotated locations for XP_008769590.1

UniProtKB/TrEMBL

D3ZJ91

Related

ENSRNOP00000105009.1, ENSRNOT00000163681.1

Conserved Domains (4) summary

smart00454
Location:386 → 445

SAM; Sterile alpha motif

pfam02825
Location:42 → 112

WWE; WWE domain

pfam02862
Location:470 → 670

DDHD; DDHD domain

cl15755
Location:379 → 447

SAM_superfamily; SAM (Sterile alpha motif )
XM_039094820.2 → XP_038950748.1 phospholipase DDHD2 isoform X3

UniProtKB/TrEMBL

D3ZJ91

Conserved Domains (3) summary

pfam02825
Location:44 → 112

WWE; WWE domain

pfam02862
Location:487 → 672

DDHD; DDHD domain

cl15755
Location:379 → 447

SAM_superfamily; SAM (Sterile alpha motif )
XM_063275721.1 → XP_063131791.1 phospholipase DDHD2 isoform X4

UniProtKB/TrEMBL

D3ZJ91
XM_006253338.4 → XP_006253400.1 phospholipase DDHD2 isoform X5

See identical proteins and their annotated locations for XP_006253400.1

UniProtKB/TrEMBL

D3ZJ91

Conserved Domains (3) summary

smart00454
Location:290 → 349

SAM; Sterile alpha motif

pfam02862
Location:391 → 591

DDHD; DDHD domain

cl15755
Location:283 → 351

SAM_superfamily; SAM (Sterile alpha motif )