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    Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499529, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ndufs4provided by RGD
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit S4provided by RGD
    Primary source
    RGD:1594380
    See related
    EnsemblRapid:ENSRNOG00000011383 AllianceGenome:RGD:1594380
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Aqdq
    Summary
    Predicted to contribute to NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in response to cAMP. Predicted to act upstream of or within several processes, including adult walking behavior; mitochondrial respiratory chain complex I assembly; and nervous system development. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Human ortholog(s) of this gene implicated in Leigh disease and nuclear type mitochondrial complex I deficiency 1. Orthologous to human NDUFS4 (NADH:ubiquinone oxidoreductase subunit S4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 981.2), Muscle (RPKM 666.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ndufs4 in Genome Data Viewer
    Location:
    2q14
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (47684420..47794914, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (45951327..46061829, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (46372488..46476162, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene biliverdin reductase A, pseudogene 1 Neighboring gene ARF like GTPase 15 Neighboring gene uncharacterized LOC120100716 Neighboring gene transfer RNA threonine (anticodon AGU) 8 Neighboring gene uncharacterized LOC120100717 Neighboring gene follistatin Neighboring gene uncharacterized LOC103691459

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 31
    Process Evidence Code Pubs
    acts_upstream_of_or_within adult behavior  
    acts_upstream_of_or_within adult walking behavior  
    involved_in biological_process  
    involved_in brain development  
    acts_upstream_of_or_within brain development  
    involved_in brain development  
    acts_upstream_of_or_within cellular response to oxygen levels  
    acts_upstream_of_or_within cognition  
    acts_upstream_of_or_within dopamine metabolic process  
    involved_in electron transport chain  
    acts_upstream_of_or_within inflammatory response  
    acts_upstream_of_or_within innate immune response  
    involved_in mitochondrial respiratory chain complex I assembly  
    acts_upstream_of_or_within mitochondrial respiratory chain complex I assembly  
    involved_in mitochondrial respiratory chain complex I assembly  
    acts_upstream_of_or_within neuron apoptotic process  
    acts_upstream_of_or_within neuron development  
    involved_in proton transmembrane transport  
    acts_upstream_of_or_within psychomotor behavior  
    involved_in reactive oxygen species metabolic process  
    acts_upstream_of_or_within reactive oxygen species metabolic process  
    involved_in reactive oxygen species metabolic process  
    acts_upstream_of_or_within regulation of mitochondrial membrane potential  
    acts_upstream_of_or_within regulation of protein phosphorylation  
    acts_upstream_of_or_within respiratory electron transport chain  
    acts_upstream_of_or_within respiratory system process  
    involved_in response to cAMP  
    involved_in response to cAMP  
    acts_upstream_of_or_within response to injury involved in regulation of muscle adaptation  
    acts_upstream_of_or_within sensory perception of sound  
    acts_upstream_of_or_within visual perception  
    Items 1 - 25 of 31
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane  
    located_in mitochondrial inner membrane  
    located_in mitochondrion  
    part_of respiratory chain complex I  
    part_of respiratory chain complex I  
    part_of respiratory chain complex I  

    General protein information

    Preferred Names
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
    Names
    CI-18 kDa
    NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
    NADH-ubiquinone oxidoreductase 18 kDa subunit
    complex I-18 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025146.1NP_001020317.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001020317.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083729
      UniProtKB/Swiss-Prot
      A1L111, Q5XIF3
      UniProtKB/TrEMBL
      A6I5S1
      Related
      ENSRNOP00000015217.3, ENSRNOT00000015217.7
      Conserved Domains (1) summary
      pfam04800
      Location:76167
      ETC_C1_NDUFA4; ETC complex I subunit conserved region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      47684420..47794914 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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