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    Rab11a RAB11a, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81830, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rab11aprovided by RGD
    Official Full Name
    RAB11a, member RAS oncogene familyprovided by RGD
    Primary source
    RGD:619762
    See related
    EnsemblRapid:ENSRNOG00000011302 AllianceGenome:RGD:619762
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables GTP binding activity and GTPase activity. Involved in several processes, including endosomal transport; regulation of long-term neuronal synaptic plasticity; and regulation of protein localization. Located in recycling endosome. Is active in Schaffer collateral - CA1 synapse; cytoplasmic vesicle; and glutamatergic synapse. Orthologous to human RAB11A (RAB11A, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 466.1), Kidney (RPKM 461.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Rab11a in Genome Data Viewer
    Location:
    8q24
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (74118922..74141760, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (65223698..65246461, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (70192975..70215719, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene DIS3-like exosome 3'-5' exoribonuclease Neighboring gene multiple EGF-like-domains 11 Neighboring gene uncharacterized LOC134480194 Neighboring gene transfer RNA glutamine (anticodon CUG) 5 Neighboring gene ribosomal protein L7, pseudogene 26

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein activity  
    enables GTP binding  
    enables GTP binding PubMed 
    enables GTP binding  
    enables GTP binding PubMed 
    enables GTPase activity  
    enables GTPase activity PubMed 
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase activity  
    enables dynein light intermediate chain binding  
    enables dynein light intermediate chain binding  
    enables microtubule binding  
    enables myosin V binding  
    enables protein domain specific binding  
    Items 1 - 25 of 49
    Process Evidence Code Pubs
    involved_in amyloid-beta clearance by transcytosis  
    involved_in astral microtubule organization  
    involved_in early endosome to recycling endosome transport  
    involved_in establishment of protein localization to membrane  
    involved_in establishment of protein localization to organelle  
    involved_in establishment of vesicle localization  
    involved_in exocytosis  
    involved_in exosomal secretion  
    involved_in intracellular cholesterol transport  
    involved_in melanosome transport  
    involved_in melanosome transport  
    involved_in melanosome transport  
    involved_in mitotic metaphase chromosome alignment  
    involved_in mitotic spindle assembly  
    involved_in multivesicular body assembly  
    involved_in neuron projection development  
    involved_in neuron projection development  
    involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane  
    involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane PubMed 
    involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane PubMed 
    involved_in positive regulation of G2/M transition of mitotic cell cycle  
    involved_in positive regulation of epithelial cell migration  
    involved_in positive regulation of mitotic cytokinetic process  
    involved_in positive regulation of protein localization to plasma membrane PubMed 
    acts_upstream_of_or_within protein localization to cell surface  
    involved_in protein localization to cilium  
    involved_in protein localization to cilium  
    involved_in protein localization to plasma membrane  
    involved_in protein localization to plasma membrane  
    acts_upstream_of_or_within protein transmembrane transport  
    involved_in protein transport  
    involved_in regulation of cilium assembly  
    involved_in regulation of cilium assembly  
    involved_in regulation of cytokinesis  
    involved_in regulation of early endosome to recycling endosome transport  
    involved_in regulation of early endosome to recycling endosome transport  
    involved_in regulation of endocytic recycling  
    involved_in regulation of endocytic recycling  
    involved_in regulation of long-term neuronal synaptic plasticity PubMed 
    involved_in regulation of protein localization to centrosome  
    involved_in regulation of protein localization to centrosome  
    involved_in regulation of protein transport PubMed 
    involved_in regulation of vesicle-mediated transport  
    involved_in synaptic vesicle endosomal processing PubMed 
    involved_in synaptic vesicle endosomal processing PubMed 
    involved_in synaptic vesicle endosomal processing PubMed 
    involved_in vesicle-mediated transport  
    involved_in vesicle-mediated transport in synapse PubMed 
    involved_in vesicle-mediated transport in synapse PubMed 
    Items 1 - 25 of 49
    Items 1 - 20 of 50
    Component Evidence Code Pubs
    is_active_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in Golgi membrane  
    located_in Golgi membrane  
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    located_in centriolar satellite  
    located_in centriole  
    located_in centrosome  
    located_in centrosome  
    located_in cleavage furrow  
    located_in cleavage furrow  
    located_in cleavage furrow  
    located_in cytoplasm  
    located_in cytoplasmic vesicle  
    located_in cytosol  
    located_in endocytic vesicle membrane  
    located_in endocytic vesicle membrane  
    located_in exocytic vesicle  
    located_in extracellular exosome  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    located_in intracellular membrane-bounded organelle  
    located_in kinetochore microtubule  
    located_in membrane  
    located_in multivesicular body  
    located_in perinuclear region of cytoplasm  
    located_in phagocytic vesicle  
    located_in phagocytic vesicle  
    located_in phagocytic vesicle  
    is_active_in postsynaptic recycling endosome  
    is_active_in postsynaptic recycling endosome  
    is_active_in presynaptic endosome PubMed 
    is_active_in presynaptic endosome PubMed 
    is_active_in presynaptic endosome PubMed 
    part_of protein-containing complex  
    located_in recycling endosome PubMed 
    located_in recycling endosome  
    located_in recycling endosome membrane  
    located_in spindle pole  
    is_active_in synaptic vesicle membrane PubMed 
    is_active_in synaptic vesicle membrane PubMed 
    located_in synaptic vesicle membrane  
    located_in trans-Golgi network  
    located_in trans-Golgi network  
    located_in trans-Golgi network membrane  
    located_in trans-Golgi network membrane  
    is_active_in transport vesicle  
    located_in vesicle  
    Items 1 - 20 of 50

    General protein information

    Preferred Names
    ras-related protein Rab-11A
    Names
    24KG
    rab-11
    NP_112414.1
    XP_063122287.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031152.3NP_112414.1  ras-related protein Rab-11A

      See identical proteins and their annotated locations for NP_112414.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      P62494
      UniProtKB/TrEMBL
      A0A8I6AA65, A6J5C6
      Related
      ENSRNOP00000015598.3, ENSRNOT00000015598.5
      Conserved Domains (1) summary
      cd01868
      Location:9173
      Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      74118922..74141760 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266217.1XP_063122287.1  ras-related protein Rab-11A isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZN41
      Related
      ENSRNOP00000079481.1, ENSRNOT00000115583.2
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