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    Plcl2 phospholipase C-like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301173, updated on 27-Dec-2024

    Summary

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    Symbol
    Plcl2provided by RGD
    Full Name
    phospholipase C-like 2provided by RGD
    Primary source
    RGD:1305941
    See related
    EnsemblRapid:ENSRNOG00000013368 AllianceGenome:RGD:1305941
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GABA receptor binding activity and phosphatidylinositol phospholipase C activity. Predicted to be involved in several processes, including gamma-aminobutyric acid signaling pathway; negative regulation of cold-induced thermogenesis; and phosphatidylinositol-mediated signaling. Predicted to act upstream of or within B cell proliferation involved in immune response; B-1a B cell differentiation; and negative regulation of B cell receptor signaling pathway. Orthologous to human PLCL2 (phospholipase C like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 342.9), Brain (RPKM 252.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plcl2 in Genome Data Viewer
    Location:
    9q11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (3529117..3713712)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (3292564..3477009)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (1782536..1984654, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094622 Neighboring gene uncharacterized LOC120094621 Neighboring gene uncharacterized LOC134480316 Neighboring gene uncharacterized LOC134480471 Neighboring gene TBC1 domain family, member 5 Neighboring gene NADH:ubiquinone oxidoreductase subunit B1, pseudogene 1 Neighboring gene ribosomal protein L10, pseudogene 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Role of phospholipase C-L2, a novel phospholipase C-like protein that lacks lipase activity, in B-cell receptor signaling. Takenaka K, et al. Mol Cell Biol, 2003 Oct. PMID 14517301, Free PMC Article
    2. Phospholipase C-related Catalytically Inactive Protein Is a New Modulator of Thermogenesis Promoted by β-Adrenergic Receptors in Brown Adipocytes. Oue K, et al. J Biol Chem, 2016 Feb 19. PMID 26706316, Free PMC Article
    3. Modulation of GABA(A) receptor phosphorylation and membrane trafficking by phospholipase C-related inactive protein/protein phosphatase 1 and 2A signaling complex underlying brain-derived neurotrophic factor-dependent regulation of GABAergic inhibition. Kanematsu T, et al. J Biol Chem, 2006 Aug 4. PMID 16754670
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GABA receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol 1,4,5 trisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell proliferation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within B-1a B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in gamma-aminobutyric acid signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in phosphatidylinositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of synaptic transmission, GABAergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of synaptic transmission, GABAergic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    inactive phospholipase C-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106880.1 → NP_001100350.1  inactive phospholipase C-like protein 2

      See identical proteins and their annotated locations for NP_001100350.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474081
      UniProtKB/TrEMBL
      A0A8I5ZYT1, A6KPP0
      Related
      ENSRNOP00000108323.1, ENSRNOT00000147406.1
      Conserved Domains (6) summary
      cd00275
      Location:627 → 755
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08597
      Location:299 → 595
      PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein
      PLN02228
      Location:209 → 757
      PLN02228; Phosphoinositide phospholipase C
      cd13364
      Location:17 → 125
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      pfam00169
      Location:19 → 125
      PH; PH domain
      pfam09279
      Location:217 → 299
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      3529117..3713712
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083165.2 → XP_038939093.1  inactive phospholipase C-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYT1, F1M324
      Conserved Domains (4) summary
      cd00275
      Location:754 → 882
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08597
      Location:426 → 722
      PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein
      cd13364
      Location:144 → 252
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd16223
      Location:272 → 415
      EFh_PRIP2; EF-hand motif found in phospholipase C-related but catalytically inactive protein 2 (PRIP-2)

    2. XM_039083164.2 → XP_038939092.1  inactive phospholipase C-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYT1, F1M324
      Related
      ENSRNOP00000018146.7, ENSRNOT00000018146.9
      Conserved Domains (4) summary
      cd00275
      Location:754 → 882
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08597
      Location:426 → 722
      PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein
      cd13364
      Location:144 → 252
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd16223
      Location:272 → 415
      EFh_PRIP2; EF-hand motif found in phospholipase C-related but catalytically inactive protein 2 (PRIP-2)

    RNA

    1. XR_010054577.1 RNA Sequence

    2. XR_010054576.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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