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    Vash2 vasohibin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498309, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Vash2provided by RGD
    Official Full Name
    vasohibin 2provided by RGD
    Primary source
    RGD:1564105
    See related
    EnsemblRapid:ENSRNOG00000003832 AllianceGenome:RGD:1564105
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564105
    Summary
    Predicted to enable actin binding activity; metallocarboxypeptidase activity; and microtubule binding activity. Predicted to be involved in axon development; proteolysis; and regulation of angiogenesis. Predicted to act upstream of or within several processes, including labyrinthine layer blood vessel development; positive regulation of angiogenesis; and positive regulation of endothelial cell proliferation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human VASH2 (vasohibin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 144.1), Testes (RPKM 70.1) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vash2 in Genome Data Viewer
    Location:
    13q27
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (105060857..105092325, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (102529718..102561204, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (109521190..109552607, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481611 Neighboring gene H3.3 histone B like 1 Neighboring gene angel homolog 2 Neighboring gene FLVCR choline and heme transporter 1 Neighboring gene spermatogenesis associated 45

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer. Zhou C, et al. Nat Commun, 2019 Jul 19. PMID 31324789, Free PMC Article
    2. Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis. Liao S, et al. Cell Res, 2019 Jul. PMID 31171830, Free PMC Article
    3. Vasohibins encode tubulin detyrosinating activity. Nieuwenhuis J, et al. Science, 2017 Dec 15. PMID 29146869
    4. Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation. Aillaud C, et al. Science, 2017 Dec 15. PMID 29146868
    5. Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis. Kimura H, et al. Blood, 2009 May 7. PMID 19204325

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metallocarboxypeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell-cell fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within labyrinthine layer blood vessel development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within labyrinthine layer development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within placenta blood vessel development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within syncytium formation by plasma membrane fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tubulinyl-Tyr carboxypeptidase 2
    NP_001381302.1
    NP_001388308.1
    XP_006250525.1
    XP_008768090.1
    XP_008768091.1
    XP_038946923.1
    XP_038946924.1
    XP_063128621.1
    XP_063128622.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394373.1 → NP_001381302.1  tubulinyl-Tyr carboxypeptidase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6JGX8
      Related
      ENSRNOP00000110878.1, ENSRNOT00000130236.1
      Conserved Domains (1) summary
      pfam14822
      Location:47 → 291
      Vasohibin

    2. NM_001401379.1 → NP_001388308.1  tubulinyl-Tyr carboxypeptidase 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      F1LT12
      Related
      ENSRNOP00000005095.6, ENSRNOT00000005095.9

    3. NM_001429850.1 → NP_001416779.1  tubulinyl-Tyr carboxypeptidase 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013

    4. NM_001429851.1 → NP_001416780.1  tubulinyl-Tyr carboxypeptidase 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      F1LT12

    5. NM_001429852.1 → NP_001416781.1  tubulinyl-Tyr carboxypeptidase 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      F1LT12

    6. NM_001429853.1 → NP_001416782.1  tubulinyl-Tyr carboxypeptidase 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013

    7. NM_001429854.1 → NP_001416783.1  tubulinyl-Tyr carboxypeptidase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6JGX8

    RNA

    1. NR_190818.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013

    2. NR_190819.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013

    3. NR_190820.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013

    4. NR_190821.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013

    5. NR_190822.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      105060857..105092325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769868.4 → XP_008768090.1  tubulinyl-Tyr carboxypeptidase 2 isoform X1

      Conserved Domains (1) summary
      pfam14822
      Location:47 → 291
      Vasohibin

    2. XM_006250463.5 → XP_006250525.1  tubulinyl-Tyr carboxypeptidase 2 isoform X2

      Conserved Domains (1) summary
      pfam14822
      Location:47 → 291
      Vasohibin; Vasohibin

    3. XM_063272551.1 → XP_063128621.1  tubulinyl-Tyr carboxypeptidase 2 isoform X2

    4. XM_039090996.2 → XP_038946924.1  tubulinyl-Tyr carboxypeptidase 2 isoform X4

      Conserved Domains (1) summary
      pfam14822
      Location:47 → 291
      Vasohibin

    5. XM_008769869.3 → XP_008768091.1  tubulinyl-Tyr carboxypeptidase 2 isoform X1

      See identical proteins and their annotated locations for XP_008768091.1

      Conserved Domains (1) summary
      pfam14822
      Location:47 → 291
      Vasohibin

    6. XM_039090995.2 → XP_038946923.1  tubulinyl-Tyr carboxypeptidase 2 isoform X3

      Conserved Domains (1) summary
      pfam14822
      Location:47 → 291
      Vasohibin

    7. XM_063272552.1 → XP_063128622.1  tubulinyl-Tyr carboxypeptidase 2 isoform X5

    RNA

    1. XR_001840789.3 RNA Sequence

    2. XR_010056932.1 RNA Sequence

    3. XR_005492277.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001109082.1: Suppressed sequence

      Description
      NM_001109082.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

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