Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mapk8ip2provided by RGD
Official Full Name: mitogen-activated protein kinase 8 interacting protein 2provided by RGD
Primary source: RGD:1309727
See related: EnsemblRapid:ENSRNOG00000032828 AllianceGenome:RGD:1309727
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: IB-2; JIP-2
Summary: Predicted to enable several functions, including JUN kinase binding activity; MAP-kinase scaffold activity; and kinesin binding activity. Involved in positive regulation of stress-activated MAPK cascade. Part of protein-containing complex. Orthologous to human MAPK8IP2 (mitogen-activated protein kinase 8 interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 117.8), Adrenal (RPKM 16.9) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (122406350..122416602)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (120526732..120536982)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (130430588..130440838)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

BF401761 (e-PCR)
- UniSTS:245540

D7Arb9 (e-PCR)
- UniSTS:259389

RH135212 (e-PCR)
- UniSTS:218489

D4S2983 (e-PCR)
- UniSTS:74945

AI847694 (e-PCR)
- UniSTS:164589

D7Arb9 (e-PCR)
- UniSTS:239611

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables JUN kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables MAP-kinase scaffold activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP-kinase scaffold activity	ISO Inferred from Sequence Orthology more info
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within JNK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in behavioral fear response	ISO Inferred from Sequence Orthology more info
involved_in dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in mating behavior	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in nonassociative learning	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress-activated MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of AMPA receptor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of NMDA receptor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of signaling receptor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in social behavior	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: C-Jun-amino-terminal kinase-interacting protein 2

Names: JNK MAP kinase scaffold protein 2; JNK-interacting protein 2; islet-brain-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100720.3 → NP_001094190.1 C-Jun-amino-terminal kinase-interacting protein 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

G3V9M2, Q3B8P9

Related

ENSRNOP00000052648.1, ENSRNOT00000055792.4

Conserved Domains (2) summary

cd11942
Location:619 → 673

SH3_JIP2; Src homology 3 domain of JNK-interacting protein 2

cd01212
Location:690 → 835

PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain