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    Got1l1 glutamic-oxaloacetic transaminase 1-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306540, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Got1l1provided by RGD
    Official Full Name
    glutamic-oxaloacetic transaminase 1-like 1provided by RGD
    Primary source
    RGD:1307172
    See related
    EnsemblRapid:ENSRNOG00000038473 AllianceGenome:RGD:1307172
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307172
    Summary
    Predicted to enable L-aspartate:2-oxoglutarate aminotransferase activity. Predicted to be involved in aspartate biosynthetic process. Predicted to be active in cytosol. Orthologous to human GOT1L1 (glutamic-oxaloacetic transaminase 1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 27.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Got1l1 in Genome Data Viewer
    Location:
    16q12.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (71563562..71576446)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (64860308..64873656)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (69022756..69035507)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4E binding protein 1 Neighboring gene adrenoceptor beta 3 Neighboring gene RAB11 family interacting protein 1 Neighboring gene BRF2 general transcription factor 3B subunit Neighboring gene adhesion G protein-coupled receptor A2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Biosynthesis of D-aspartate in mammals: the rat and human homologs of mouse aspartate racemase are not responsible for the biosynthesis of D-aspartate. Matsuda S, et al. Amino Acids, 2015 May. PMID 25646960
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The rat and human homologs of mouse GOT1L1 are not involved in D-aspartate biosynthesis.
      Title: Biosynthesis of D-aspartate in mammals: the rat and human homologs of mouse aspartate racemase are not responsible for the biosynthesis of D-aspartate.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-aspartate:2-oxoglutarate aminotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aspartate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative aspartate aminotransferase, cytoplasmic 2
    NP_001014025.2
    XP_006253354.1
    XP_006253356.1
    XP_017455630.1
    XP_038950478.1
    XP_038950480.1
    XP_038950481.1
    XP_063131509.1
    XP_063131510.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014003.2 → NP_001014025.2  putative aspartate aminotransferase, cytoplasmic 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A0U1RVK4
      Related
      ENSRNOP00000109387.1, ENSRNOT00000130627.1
      Conserved Domains (1) summary
      cl18945
      Location:5 → 399
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      71563562..71576446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253292.4 → XP_006253354.1  putative aspartate aminotransferase, cytoplasmic 2 isoform X2

      Related
      ENSRNOP00000033792.7, ENSRNOT00000035985.8
      Conserved Domains (2) summary
      pfam00155
      Location:9 → 355
      Aminotran_1_2; Aminotransferase class I and II
      cl18945
      Location:2 → 359
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    2. XM_017600141.2 → XP_017455630.1  putative aspartate aminotransferase, cytoplasmic 2 isoform X2

      Conserved Domains (2) summary
      pfam00155
      Location:9 → 355
      Aminotran_1_2; Aminotransferase class I and II
      cl18945
      Location:2 → 359
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    3. XM_039094550.2 → XP_038950478.1  putative aspartate aminotransferase, cytoplasmic 2 isoform X1

      Conserved Domains (1) summary
      cl18945
      Location:5 → 393
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    4. XM_006253294.5 → XP_006253356.1  putative aspartate aminotransferase, cytoplasmic 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZVR3
      Related
      ENSRNOP00000083655.1, ENSRNOT00000097132.2
      Conserved Domains (1) summary
      cl18945
      Location:5 → 256
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    5. XM_039094552.1 → XP_038950480.1  putative aspartate aminotransferase, cytoplasmic 2 isoform X5

      Conserved Domains (1) summary
      cl18945
      Location:2 → 254
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    6. XM_039094553.1 → XP_038950481.1  putative aspartate aminotransferase, cytoplasmic 2 isoform X5

      Conserved Domains (1) summary
      cl18945
      Location:2 → 254
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    7. XM_063275439.1 → XP_063131509.1  putative aspartate aminotransferase, cytoplasmic 2 isoform X4

      UniProtKB/TrEMBL
      D4A1Z9, Q6AY54

    8. XM_063275440.1 → XP_063131510.1  putative aspartate aminotransferase, cytoplasmic 2 isoform X4

      UniProtKB/TrEMBL
      D4A1Z9, Q6AY54
      Related
      ENSRNOP00000075776.1, ENSRNOT00000092635.3

    RNA

    1. XR_001841538.3 RNA Sequence

    2. XR_010058296.1 RNA Sequence

    3. XR_001841540.3 RNA Sequence

    4. XR_005494617.2 RNA Sequence

    5. XR_005494619.2 RNA Sequence

    6. XR_005494620.2 RNA Sequence

    7. XR_005494622.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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