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    Rnf31 ring finger protein 31 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364386, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rnf31provided by RGD
    Official Full Name
    ring finger protein 31provided by RGD
    Primary source
    RGD:1305513
    See related
    EnsemblRapid:ENSRNOG00000019438 AllianceGenome:RGD:1305513
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including linear polyubiquitin binding activity; polyubiquitin modification-dependent protein binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; positive regulation of NF-kappaB transcription factor activity; and positive regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within negative regulation of necroptotic process. Predicted to be located in cytoplasmic side of plasma membrane and cytosol. Predicted to be part of CD40 receptor complex and LUBAC complex. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human RNF31 (ring finger protein 31). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 66.5), Spleen (RPKM 64.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Rnf31 in Genome Data Viewer
    Location:
    15p13
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (33053450..33065285)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (29083047..29095328)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34270037..34282385)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene proteasome activator subunit 1 Neighboring gene ER membrane protein complex subunit 9 Neighboring gene proteasome activator subunit 2 Neighboring gene interferon regulatory factor 9 Neighboring gene small ribosomal subunit protein uS19-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables K48-linked polyubiquitin modification-dependent protein binding  
    enables K63-linked polyubiquitin modification-dependent protein binding  
    enables identical protein binding  
    enables linear polyubiquitin binding  
    enables ubiquitin binding  
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase binding  
    enables ubiquitin-protein transferase activity  
    enables zinc ion binding  
    Component Evidence Code Pubs
    part_of CD40 receptor complex  
    part_of LUBAC complex  
    located_in cytoplasmic side of plasma membrane  
    located_in cytosol  

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RNF31
    NP_001102338.2
    XP_006252062.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108868.1NP_001102338.2  E3 ubiquitin-protein ligase RNF31

      See identical proteins and their annotated locations for NP_001102338.2

      Status: PROVISIONAL

      Source sequence(s)
      CH474049
      UniProtKB/TrEMBL
      A0A8I6A2Y9, A6KH19, E9PU29
      Related
      ENSRNOP00000026333.5, ENSRNOT00000026333.9
      Conserved Domains (7) summary
      smart00647
      Location:769831
      IBR; In Between Ring fingers
      cd14325
      Location:561615
      UBA_RNF31; UBA domain found in E3 ubiquitin-protein ligase RING finger protein 31 and similar proteins
      sd00029
      Location:348367
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam04981
      Location:689739
      NMD3; NMD3 family
      pfam16678
      Location:473617
      HOIP-UBA; UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase
      cl00873
      Location:523594
      PdxA; Pyridoxal phosphate biosynthetic protein PdxA
      cl15262
      Location:51152
      PUB; PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      33053450..33065285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006252000.5XP_006252062.1  E3 ubiquitin-protein ligase RNF31 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A2Y9
      Conserved Domains (8) summary
      smart00647
      Location:768830
      IBR; In Between Ring fingers
      cd14325
      Location:560614
      UBA_RNF31; UBA domain found in E3 ubiquitin-protein ligase RING finger protein 31 and similar proteins
      sd00029
      Location:348367
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam04981
      Location:688738
      NMD3; NMD3 family
      pfam14636
      Location:365516
      FNIP_N; Folliculin-interacting protein N-terminus
      pfam16678
      Location:472616
      HOIP-UBA; UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase
      cl00873
      Location:522593
      PdxA; Pyridoxal phosphate biosynthetic protein PdxA
      cl15262
      Location:51152
      PUB; PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins
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