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    Spo11 SPO11 initiator of meiotic double strand breaks [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366261, updated on 9-Dec-2024

    Summary

    Official Symbol
    Spo11provided by RGD
    Official Full Name
    SPO11 initiator of meiotic double strand breaksprovided by RGD
    Primary source
    RGD:1306454
    See related
    EnsemblRapid:ENSRNOG00000006732 AllianceGenome:RGD:1306454
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in meiotic DNA double-strand break formation; meiotic DNA double-strand break processing; and reciprocal meiotic recombination. Predicted to act upstream of or within several processes, including germ cell development; meiosis I; and ovarian follicle development. Predicted to be located in chromosome, telomeric region. Predicted to be active in nuclear chromosome. Orthologous to human SPO11 (SPO11 initiator of meiotic double strand breaks). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 84.8), Kidney (RPKM 27.9) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Spo11 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (182173615..182189273)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (161755299..161770930)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (170991573..171008226)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486499 Neighboring gene bone morphogenetic protein 7 Neighboring gene uncharacterized LOC134486500 Neighboring gene ribonucleic acid export 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables DNA binding  
    enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity  
    enables metal ion binding  
    Component Evidence Code Pubs
    located_in chromosome, telomeric region  
    is_active_in nuclear chromosome  

    General protein information

    Preferred Names
    meiotic recombination protein SPO11
    Names
    SPO11 meiotic protein covalently bound to DSB homolog
    SPO11, initiator of meiotic double stranded breaks
    sporulation protein, meiosis-specific, SPO11 homolog
    NP_001402745.1
    XP_038961537.1
    XP_038961538.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415816.1NP_001402745.1  meiotic recombination protein SPO11

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      D3Z8A8
      Related
      ENSRNOP00000008959.4, ENSRNOT00000008959.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      182173615..182189273
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105610.2XP_038961538.1  meiotic recombination protein SPO11 isoform X2

      UniProtKB/TrEMBL
      A6KKY2
      Conserved Domains (1) summary
      COG1697
      Location:29280
      Spo11; DNA topoisomerase VI, subunit A [Replication, recombination and repair]
    2. XM_039105609.2XP_038961537.1  meiotic recombination protein SPO11 isoform X1

      Conserved Domains (2) summary
      COG1697
      Location:43360
      Spo11; DNA topoisomerase VI, subunit A [Replication, recombination and repair]
      pfam03533
      Location:244
      SPO11_like; SPO11 homolog

    RNA

    1. XR_005501952.2 RNA Sequence

    2. XR_005501951.2 RNA Sequence

    3. XR_005501953.2 RNA Sequence

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