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    Abo3 histo-blood group ABO system transferase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65270, updated on 9-Dec-2024

    Summary

    Official Symbol
    Abo3provided by RGD
    Official Full Name
    histo-blood group ABO system transferase 3provided by RGD
    Primary source
    RGD:628609
    See related
    EnsemblRapid:ENSRNOG00000039906 AllianceGenome:RGD:628609
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Abo; Abol1
    Summary
    Enables glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity. Involved in defense response to bacterium. Predicted to be located in Golgi cisterna membrane and extracellular region. Predicted to be active in Golgi apparatus and vesicle. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; graft-versus-host disease; leukemia (multiple); lung disease (multiple); and severe acute respiratory syndrome. Orthologous to human ABO (ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 4.9), Heart (RPKM 3.3) and 9 other tissues See more
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    Genomic context

    See Abo3 in Genome Data Viewer
    Location:
    3p13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (30141941..30159129)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (9743861..9761049)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (5109880..5127376)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene vomeronasal secretory protein 2-like Neighboring gene glutamic-oxaloacetic transaminase 2, pseudogene 5 Neighboring gene lipocalin 4 Neighboring gene uncharacterized LOC134486061

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process  
    involved_in defense response to bacterium PubMed 
    involved_in lipid glycosylation  
    involved_in protein glycosylation  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus  
    located_in Golgi cisterna membrane  
    located_in extracellular region  
    located_in membrane  
    is_active_in vesicle  

    General protein information

    Preferred Names
    histo-blood group ABO system transferase 1
    Names
    ABO blood group (alpha 1-3-N-acetylgalactosaminyltransferase, alpha 1-3-galactosyltransferase)
    ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase
    ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
    ABO blood group (transferase B, alpha 1-3-galactosyltransferase)
    ABO blood group-like 1
    B blood group galactosyltransferase
    N-acetylgalactosaminyltransferase A blood group-like enzyme
    NAGAT 1
    a transferase
    alpha 1-3-N-acetylgalactosaminyltransferase-like 1
    b transferase
    blood group A glycosyltransferase 1
    cis-AB transferase 1
    fucosylglycoprotein 3-alpha-galactosyltransferase
    fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase
    globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
    glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase
    glycoprotein-fucosylgalactoside alpha-galactosyltransferase
    histo-blood group A transferase
    histo-blood group B transferase
    transferase B, alpha 1-3-galactosyltransferase)
    NP_075582.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023094.4NP_075582.3  histo-blood group ABO system transferase 1

      See identical proteins and their annotated locations for NP_075582.3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q8CFC5, Q8CFC6, Q8R005, Q8R4Y3, Q8R552, Q9ET32
      UniProtKB/TrEMBL
      A0A0H2UI32
      Related
      ENSRNOP00000006553.7, ENSRNOT00000006553.9
      Conserved Domains (1) summary
      pfam03414
      Location:59348
      Glyco_transf_6; Glycosyltransferase family 6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      30141941..30159129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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