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    Ube2e3 ubiquitin-conjugating enzyme E2E 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295686, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ube2e3provided by RGD
    Official Full Name
    ubiquitin-conjugating enzyme E2E 3provided by RGD
    Primary source
    RGD:1308894
    See related
    AllianceGenome:RGD:1308894
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein K11-linked ubiquitination; protein K48-linked ubiquitination; and protein K63-linked ubiquitination. Predicted to be active in nucleus. Orthologous to human UBE2E3 (ubiquitin conjugating enzyme E2 E3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 216.8), Heart (RPKM 181.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ube2e3 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (84194246..84250232)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (63786976..63851400)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (65815076..65876256)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene programmed cell death 5 like 1 Neighboring gene uncharacterized LOC120101585 Neighboring gene uncharacterized LOC102552685 Neighboring gene integrin subunit alpha 4 Neighboring gene CERK like autophagy regulator

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables ubiquitin conjugating enzyme activity  
    enables ubiquitin conjugating enzyme activity  
    enables ubiquitin-protein transferase activity  
    Process Evidence Code Pubs
    involved_in protein K11-linked ubiquitination  
    involved_in protein K11-linked ubiquitination  
    involved_in protein K48-linked ubiquitination  
    involved_in protein K48-linked ubiquitination  
    involved_in protein K63-linked ubiquitination  
    involved_in protein K63-linked ubiquitination  
    Component Evidence Code Pubs
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 E3
    NP_001041322.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047857.4NP_001041322.2  ubiquitin-conjugating enzyme E2 E3

      See identical proteins and their annotated locations for NP_001041322.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HMK5
      Conserved Domains (1) summary
      pfam00179
      Location:65202
      UQ_con; Ubiquitin-conjugating enzyme

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      84194246..84250232
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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