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    Asic1 acid sensing ion channel subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79123, updated on 9-Dec-2024

    Summary

    Official Symbol
    Asic1provided by RGD
    Official Full Name
    acid sensing ion channel subunit 1provided by RGD
    Primary source
    RGD:71062
    See related
    EnsemblRapid:ENSRNOG00000059765 AllianceGenome:RGD:71062
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Accn2
    Summary
    Enables inorganic cation transmembrane transporter activity and pH-gated monoatomic ion channel activity. Involved in monoatomic ion transmembrane transport. Acts upstream of or within inorganic cation transmembrane transport. Located in cell surface and membrane. Orthologous to human ASIC1 (acid sensing ion channel subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 56.3), Lung (RPKM 29.5) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Asic1 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (132677158..132707379)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (130798317..130828535)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (141324714..141354937)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene Rac GTPase-activating protein 1 Neighboring gene uncharacterized LOC134479572 Neighboring gene SWI/SNF related BAF chromatin remodeling complex subunit D1 Neighboring gene glycerol-3-phosphate dehydrogenase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within associative learning  
    acts_upstream_of_or_within behavioral fear response  
    acts_upstream_of_or_within calcium ion transmembrane transport  
    involved_in cellular response to pH  
    involved_in cellular response to pH  
    acts_upstream_of_or_within establishment of localization in cell  
    acts_upstream_of_or_within inorganic cation transmembrane transport PubMed 
    acts_upstream_of_or_within memory  
    acts_upstream_of_or_within monoatomic cation transport  
    involved_in monoatomic ion transmembrane transport  
    involved_in monoatomic ion transmembrane transport PubMed 
    acts_upstream_of_or_within monoatomic ion transmembrane transport  
    acts_upstream_of_or_within negative regulation of neurotransmitter secretion  
    acts_upstream_of neurotransmitter secretion  
    involved_in protein homotrimerization  
    acts_upstream_of_or_within regulation of membrane potential  
    involved_in regulation of postsynapse assembly  
    acts_upstream_of_or_within response to acidic pH  
    acts_upstream_of_or_within response to amphetamine  
    involved_in sensory perception of sour taste  
    involved_in sodium ion transmembrane transport  
    involved_in sodium ion transmembrane transport  
    involved_in sodium ion transmembrane transport  
    involved_in sodium ion transmembrane transport  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in cell surface PubMed 
    is_active_in glutamatergic synapse  
    located_in membrane PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynaptic density membrane  
    located_in presynapse  
    located_in synapse  

    General protein information

    Preferred Names
    acid-sensing ion channel 1
    Names
    BNaC2
    acid-sensing (proton-gated) ion channel 1
    amiloride-sensitive cation channel 2, neuronal
    brain sodium channel 2
    proton gated cation channel ASIC1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001414903.1NP_001401832.1  acid-sensing ion channel 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      O88762, P55926, Q91YB8, Q99NA1
      UniProtKB/TrEMBL
      A0A8L2R026, A6KCG6
    2. NM_024154.3NP_077068.1  acid-sensing ion channel 1

      See identical proteins and their annotated locations for NP_077068.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      O88762, P55926, Q91YB8, Q99NA1
      UniProtKB/TrEMBL
      A0A8L2R026, A6KCG6
      Conserved Domains (1) summary
      TIGR00859
      Location:19508
      ENaC; sodium channel transporter

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      132677158..132707379
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595126.3XP_017450615.1  acid-sensing ion channel 1 isoform X3

      UniProtKB/TrEMBL
      A0A8L2R026
      Conserved Domains (1) summary
      TIGR00859
      Location:19509
      ENaC; sodium channel transporter
    2. XM_039079937.2XP_038935865.1  acid-sensing ion channel 1 isoform X4

      Conserved Domains (1) summary
      cl02990
      Location:1381
      ASC; Amiloride-sensitive sodium channel
    3. XM_017595125.3XP_017450614.1  acid-sensing ion channel 1 isoform X3

      UniProtKB/TrEMBL
      A0A8L2R026
      Conserved Domains (1) summary
      TIGR00859
      Location:19509
      ENaC; sodium channel transporter
    4. XM_063264284.1XP_063120354.1  acid-sensing ion channel 1 isoform X1

    5. XM_006257378.5XP_006257440.1  acid-sensing ion channel 1 isoform X2

      See identical proteins and their annotated locations for XP_006257440.1

      UniProtKB/TrEMBL
      A6KCG7
      Related
      ENSRNOP00000072206.2, ENSRNOT00000077175.3
      Conserved Domains (1) summary
      cl02990
      Location:63541
      ASC; Amiloride-sensitive sodium channel
    6. XM_063264285.1XP_063120355.1  acid-sensing ion channel 1 isoform X5

    7. XM_063264286.1XP_063120356.1  acid-sensing ion channel 1 isoform X6

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