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    Mkrn2 makorin, ring finger protein, 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297525, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Mkrn2provided by RGD
    Official Full Name
    makorin, ring finger protein, 2provided by RGD
    Primary source
    RGD:1310618
    See related
    EnsemblRapid:ENSRNOG00000009176 AllianceGenome:RGD:1310618
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of inflammatory response to antigenic stimulus; negative regulation of non-canonical NF-kappaB signal transduction; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and nucleus. Orthologous to human MKRN2 (makorin ring finger protein 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Heart (RPKM 132.3), Muscle (RPKM 130.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mkrn2 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (150334164..150352271)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (148661529..148679580)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (147514041..147532086)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene tRNA splicing endonuclease subunit 2 Neighboring gene MKRN2 opposite strand Neighboring gene Raf-1 proto-oncogene, serine/threonine kinase Neighboring gene small nucleolar RNA SNORA17 Neighboring gene transmembrane protein 40

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic conservation of the makorin-2 gene, encoding a multiple zinc-finger protein, antisense to the RAF1 proto-oncogene. Gray TA, et al. Genomics, 2001 Oct. PMID 11597136
    2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC95133

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of inflammatory response to antigenic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase makorin-2
    Names
    probable E3 ubiquitin-protein ligase makorin-2
    NP_001008315.1
    XP_038963349.1
    XP_038963350.1
    XP_038963351.1
    XP_038963352.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008314.1 → NP_001008315.1  E3 ubiquitin-protein ligase makorin-2

      Status: PROVISIONAL

      Source sequence(s)
      BC083870
      UniProtKB/TrEMBL
      F7EMI5, Q5XI23
      Related
      ENSRNOP00000091392.1, ENSRNOT00000114812.2
      Conserved Domains (4) summary
      PHA03096
      Location:179 → 328
      PHA03096; p28-like protein; Provisional
      cd16731
      Location:236 → 293
      RING-HC_MKRN2; RING finger, HC subclass, found in makorin-2 (MKRN2) and similar proteins
      pfam18044
      Location:6 → 27
      zf-CCCH_4; CCCH-type zinc finger
      pfam18345
      Location:37 → 55
      zf_CCCH_4; Zinc finger domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      150334164..150352271
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107424.2 → XP_038963352.1  E3 ubiquitin-protein ligase makorin-2 isoform X3

      Conserved Domains (3) summary
      PHA03096
      Location:37 → 186
      PHA03096; p28-like protein; Provisional
      COG5252
      Location:159 → 232
      COG5252; Uncharacterized conserved protein, contains CCCH-type Zn-finger protein [General function prediction only]
      cd16731
      Location:94 → 151
      RING-HC_MKRN2; RING finger, HC subclass, found in makorin-2 (MKRN2) and similar proteins

    2. XM_039107421.2 → XP_038963349.1  E3 ubiquitin-protein ligase makorin-2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GIE7, A6IKY9
      Conserved Domains (3) summary
      PHA03096
      Location:136 → 285
      PHA03096; p28-like protein; Provisional
      cd16731
      Location:193 → 250
      RING-HC_MKRN2; RING finger, HC subclass, found in makorin-2 (MKRN2) and similar proteins
      pfam18345
      Location:285 → 305
      zf_CCCH_4; Zinc finger domain

    3. XM_039107423.2 → XP_038963351.1  E3 ubiquitin-protein ligase makorin-2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GIE7
      Conserved Domains (3) summary
      PHA03096
      Location:88 → 237
      PHA03096; p28-like protein; Provisional
      COG5252
      Location:210 → 283
      COG5252; Uncharacterized conserved protein, contains CCCH-type Zn-finger protein [General function prediction only]
      cd16731
      Location:145 → 202
      RING-HC_MKRN2; RING finger, HC subclass, found in makorin-2 (MKRN2) and similar proteins

    4. XM_039107422.2 → XP_038963350.1  E3 ubiquitin-protein ligase makorin-2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GIE7
      Conserved Domains (3) summary
      PHA03096
      Location:88 → 237
      PHA03096; p28-like protein; Provisional
      COG5252
      Location:210 → 283
      COG5252; Uncharacterized conserved protein, contains CCCH-type Zn-finger protein [General function prediction only]
      cd16731
      Location:145 → 202
      RING-HC_MKRN2; RING finger, HC subclass, found in makorin-2 (MKRN2) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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