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    Eif4enif1 eukaryotic translation initiation factor 4E nuclear import factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305468, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eif4enif1provided by RGD
    Official Full Name
    eukaryotic translation initiation factor 4E nuclear import factor 1provided by RGD
    Primary source
    RGD:1560908
    See related
    EnsemblRapid:ENSRNOG00000018475 AllianceGenome:RGD:1560908
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560908
    Summary
    Predicted to enable kinase binding activity; mRNA binding activity; and nuclear export signal receptor activity. Predicted to be involved in several processes, including P-body assembly; protein import into nucleus; and regulation of mRNA catabolic process. Predicted to act upstream of with a positive effect on miRNA-mediated gene silencing by inhibition of translation. Predicted to act upstream of or within negative regulation of neuron differentiation and stem cell population maintenance. Predicted to be located in P-body; cytosol; and intracellular membrane-bounded organelle. Predicted to be active in cytoplasm and nucleus. Orthologous to human EIF4ENIF1 (eukaryotic translation initiation factor 4E nuclear import factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 98.5), Spleen (RPKM 79.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eif4enif1 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (82280566..82328559)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (78056115..78099846)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (83412843..83455694)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene phosphatidylserine decarboxylase Neighboring gene SFI1 centrin binding protein Neighboring gene uncharacterized LOC134481863 Neighboring gene small nuclear ribonucleoprotein polypeptide G, pseudogene 1 Neighboring gene developmentally regulated GTP binding protein 1 Neighboring gene U7 small nuclear RNA Neighboring gene POZ (BTB) and AT hook containing zinc finger 1 Neighboring gene LIM domain kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E. Dostie J, et al. EMBO J, 2000 Jun 15. PMID 10856257, Free PMC Article
    2. Clast4, the murine homologue of human eIF4E-Transporter, is highly expressed in developing oocytes and post-translationally modified at meiotic maturation. Villaescusa JC, et al. Gene, 2006 Feb 15. PMID 16343815
    3. An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program. Yang G, et al. Neuron, 2014 Nov 19. PMID 25456498
    4. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear export signal receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in P-body assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_positive_effect miRNA-mediated gene silencing by inhibition of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear export IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4E transporter

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107230.1 → NP_001100700.1  eukaryotic translation initiation factor 4E transporter

      See identical proteins and their annotated locations for NP_001100700.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473963
      UniProtKB/TrEMBL
      A0A8I6AC32, A6IK92, A6IK93, D4ACF1
      Related
      ENSRNOP00000089592.1, ENSRNOT00000096884.2
      Conserved Domains (1) summary
      pfam10477
      Location:30 → 711
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      82280566..82328559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251291.5 → XP_006251353.1  eukaryotic translation initiation factor 4E transporter isoform X2

      See identical proteins and their annotated locations for XP_006251353.1

      UniProtKB/TrEMBL
      A0A8I6AC32, A6IK92, A6IK93, D4ACF1
      Conserved Domains (1) summary
      pfam10477
      Location:30 → 711
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

    2. XM_006251290.5 → XP_006251352.1  eukaryotic translation initiation factor 4E transporter isoform X1

      UniProtKB/TrEMBL
      A0A8I6A9M0, A0A8I6AC32, A6IK93
      Related
      ENSRNOP00000089338.1, ENSRNOT00000102028.2
      Conserved Domains (1) summary
      pfam10477
      Location:49 → 730
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
    Nucleotide Protein Strain
    Heading Accession and Version

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