Nme3 NME/NM23 nucleoside diphosphate kinase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nme3provided by RGD
Official Full Name: NME/NM23 nucleoside diphosphate kinase 3provided by RGD
Primary source: RGD:619879
See related: EnsemblRapid:ENSRNOG00000015749 AllianceGenome:RGD:619879
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: NM23-dr
Summary: Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in DNA repair; mitochondrial fusion; and nucleoside triphosphate biosynthetic process. Predicted to be located in ciliary basal body and mitochondrial outer membrane. Orthologous to human NME3 (NME/NM23 nucleoside diphosphate kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 168.1), Kidney (RPKM 148.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (14421922..14422878)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (13917309..13918415)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (14258232..14259365)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH143979 (e-PCR)
- UniSTS:233225

RH129468 (e-PCR)
- UniSTS:212774

AI575323 (e-PCR)
- UniSTS:260915

AV001970 (e-PCR)
- UniSTS:166034

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside diphosphate kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in CTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in GTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in UTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
involved_in mitochondrial fusion	ISO Inferred from Sequence Orthology more info
involved_in nucleoside triphosphate biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: nucleoside diphosphate kinase 3

Names: expressed in non-metastatic cells 3, protein (nucleoside diphosphate kinase); non-metastatic cell expressed protein 3; non-metastatic cells 3, protein expressed in

NP_445959.1

EC 2.7.4.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053507.1 → NP_445959.1 nucleoside diphosphate kinase 3 precursor

See identical proteins and their annotated locations for NP_445959.1

Status: PROVISIONAL

Source sequence(s)

AY017337

UniProtKB/TrEMBL

A6HCY6, G3V816, Q99NI1

Related

ENSRNOP00000021650.1, ENSRNOT00000021650.4

Conserved Domains (2) summary

cd04413
Location:22 → 151

NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...

pfam00334
Location:22 → 156

NDK; Nucleoside diphosphate kinase