Nxph1 neurexophilin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nxph1provided by RGD
Official Full Name: neurexophilin 1provided by RGD
Primary source: RGD:3218
See related: AllianceGenome:RGD:3218
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable signaling receptor binding activity. Predicted to be involved in modulation of chemical synaptic transmission. Predicted to be active in GABA-ergic synapse; glutamatergic synapse; and synaptic cleft. Orthologous to human NXPH1 (neurexophilin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 147.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 4q21

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (37964325..38277364)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (36998068..37311135)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (34959721..35281017)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NRXN1alpha KO rats were found to present with large and persistent nonsocial deficits, including hyperactivity, deficits in simple instrumental learning, latent inhibition, and spatial-dependent learning.
Title: Phenotypic characterization of nonsocial behavioral impairment in neurexin 1α knockout rats.
Dystroglycan binding to alpha-neurexin competes with neurexophilin-1 and neuroligin in the brain.
Title: Dystroglycan binding to α-neurexin competes with neurexophilin-1 and neuroligin in the brain.
Study on the expression of NXPH1 in the developing and adult olfactory bulb
Title: Expression of neurexin ligands, the neuroligins and the neurexophilins, in the developing and adult rodent olfactory bulb.

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General gene information

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Markers

D4Got21 (e-PCR)
- UniSTS:112387

D4RAT115 (e-PCR)
- UniSTS:121945

BF417863 (e-PCR)
- UniSTS:249698

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in synaptic cleft	IEA Inferred from Electronic Annotation more info
is_active_in synaptic cleft	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neurexophilin-1

Names: neurophilin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.