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    Aadac arylacetamide deacetylase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 57300, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aadacprovided by RGD
    Official Full Name
    arylacetamide deacetylaseprovided by RGD
    Primary source
    RGD:631440
    See related
    EnsemblRapid:ENSRNOG00000013950 AllianceGenome:RGD:631440
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Aada
    Summary
    Predicted to enable deacetylase activity; serine hydrolase activity; and triacylglycerol lipase activity. Predicted to be involved in positive regulation of triglyceride catabolic process. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human AADAC (arylacetamide deacetylase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 358.6) and Kidney (RPKM 50.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aadac in Genome Data Viewer
    Location:
    2q31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (146293449..146351061)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (144163436..144186086)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (150146234..150157480)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene AADACL2 family member 2 like 1 Neighboring gene uncharacterized LOC134485919 Neighboring gene arylacetamide deacetylase-like 2 Neighboring gene uncharacterized LOC134485920 Neighboring gene succinate receptor 1 Neighboring gene uncharacterized LOC102551458

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Arylacetamide deacetylase attenuates fatty-acid-induced triacylglycerol accumulation in rat hepatoma cells. Lo V, et al. J Lipid Res, 2010 Feb. PMID 19654421, Free PMC Article
    2. Human arylacetamide deacetylase is a principal enzyme in flutamide hydrolysis. Watanabe A, et al. Drug Metab Dispos, 2009 Jul. PMID 19339378
    3. Human carboxylesterases and their role in xenobiotic and endobiotic metabolism. Ross MK, et al. J Biochem Mol Toxicol, 2007. PMID 17936933
    4. Targeting proteins to the lumen of endoplasmic reticulum using N-terminal domains of 11beta-hydroxysteroid dehydrogenase and the 50-kDa esterase. Mziaut H, et al. J Biol Chem, 1999 May 14. PMID 10318829
    5. Determination of lumenal orientation of microsomal 50-kDa esterase/N-deacetylase. Ozols J. Biochemistry, 1998 Jul 14. PMID 9665742

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables deacetylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables serine hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables triacylglycerol lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables triacylglycerol lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables triacylglycerol lipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of triglyceride catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of triglyceride catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of triglyceride catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    arylacetamide deacetylase
    Names
    arylacetamide deacetylase (esterase)
    NP_065413.1
    XP_063138494.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020538.1 → NP_065413.1  arylacetamide deacetylase

      See identical proteins and their annotated locations for NP_065413.1

      Status: PROVISIONAL

      Source sequence(s)
      AF182426
      UniProtKB/Swiss-Prot
      Q9QZH8
      UniProtKB/TrEMBL
      A0A9K3Y8C2, F7F0B9, Q5I0N0
      Related
      ENSRNOP00000018761.3, ENSRNOT00000018761.6
      Conserved Domains (2) summary
      COG0657
      Location:88 → 373
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam07859
      Location:106 → 373
      Abhydrolase_3; alpha/beta hydrolase fold

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      146293449..146351061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282424.1 → XP_063138494.1  arylacetamide deacetylase isoform X1

    RNA

    1. XR_010063658.1 RNA Sequence

    2. XR_005500357.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZH8.3 GenPept UniProtKB/Swiss-Prot:Q9QZH8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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