Alpi alkaline phosphatase, intestinal [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Alpiprovided by RGD
Official Full Name: alkaline phosphatase, intestinalprovided by RGD
Primary source: RGD:2099
See related: EnsemblRapid:ENSRNOG00000030020 AllianceGenome:RGD:2099
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Alp1; S51097
Summary: Enables alkaline phosphatase activity; metal ion binding activity; and protein homodimerization activity. Involved in dephosphorylation. Located in external side of plasma membrane. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to several human genes including ALPI (alkaline phosphatase, intestinal). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 3.7), Testes (RPKM 2.0) and 9 other tissues See more
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Genomic context

Location:: 9q35

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (95221314..95224780, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (87773411..87776877, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (94197616..94201910, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prematurity and formula feeding are associated with inhibition of intestinal alkaline phosphatase expression and activity. Both may increase the risk of necrotizing enterocolitis.
Title: Factors Known to Influence the Development of Necrotizing Enterocolitis to Modify Expression and Activity of Intestinal Alkaline Phosphatase in a Newborn Neonatal Rat Model.
The present study showed that dietary glucomannan elevates colonic ALP activity by up-regulation of the expression of IAP-I which is associated with increased production of protective factors for gut epithelial homeostasis in high-fat diet-fed rats.
Title: Glucomannan consumption elevates colonic alkaline phosphatase activity by up-regulating the expression of IAP-I, which is associated with increased production of protective factors for gut epithelial homeostasis in high-fat diet-fed rats.
Deficiency of IAP in the newborn rat intestine is associated with dysbiosis and increased inflammation, permeability, and bacterial translocation.
Title: Intestinal alkaline phosphatase deficiency leads to dysbiosis and bacterial translocation in the newborn intestine.
A temporal and spatial distribution of goblet cells and intestinal alkaline phosphatase activity occurs during the development of the small intestine, suggesting a possible regulatory control in accordance with the suckling and weaning phases of food intake in the rat's life.
Title: Goblet cells and intestinal Alkaline phosphatase expression (IAP) during the development of the rat small intestine.
Crystal structure of rat intestinal alkaline phosphatase protein.
Title: Crystal structure of rat intestinal alkaline phosphatase--role of crown domain in mammalian alkaline phosphatases.
Perinatal undernutrition alters intestinal alkaline phosphatase expression in adult offspring fed a high-fat diet.
Title: Perinatal undernutrition alters intestinal alkaline phosphatase and its main transcription factors KLF4 and Cdx1 in adult offspring fed a high-fat diet.
Data suggest that increased dietary calcium in intestinal lumen increases activity of Alpi (possibly through activation via molecular aggregation) and simultaneously decreases calcium entry at brush border and thus regulates calcium absorption.
Title: Luminal calcium concentration controls intestinal calcium absorption by modification of intestinal alkaline phosphatase activity.
Suggest role for lysophosphatidylcholine in brush-border intestinal alkaline phosphatase release and restoration.
Title: Role of lysophosphatidylcholine in brush-border intestinal alkaline phosphatase release and restoration.
These data are consistent with the presence of a triad of zinc atoms at the active site of rat intestinal alkaline phosphatase isozymes rIAP-I, but not rIAP-II or human placental alkaline phosphatase.
Title: Characterization of structural and catalytic differences in rat intestinal alkaline phosphatase isozymes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alkaline phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alkaline phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables alkaline phosphatase activity	IEA Inferred from Electronic Annotation more info
enables alkaline phosphatase activity	TAS Traceable Author Statement more info	PubMed
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to BMP stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to BMP stimulus	ISO Inferred from Sequence Orthology more info
involved_in dephosphorylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: intestinal-type alkaline phosphatase 1

Names: Alkaline phosphatase 1, intestinal, defined by SSR; IAP-1; IAP-I; intestinal alkaline phosphatase 1; intestinal alkaline phosphatase I IAP-I

NP_073156.3

EC 3.1.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.