Klrh1 killer cell lectin-like receptor subfamily H, member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Klrh1provided by RGD
Official Full Name: killer cell lectin-like receptor subfamily H, member 1provided by RGD
Primary source: RGD:621452
See related: EnsemblRapid:ENSRNOG00000059182 AllianceGenome:RGD:621452
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables antigen binding activity. Predicted to be involved in cellular response to molecule of fungal origin. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 2.9), Heart (RPKM 1.7) and 3 other tissues See more
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Genomic context

Location:: 4q42

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (164974238..164987987, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (163288228..163301977, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (163595909..163611383, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RT1-A2 MHC class I antigen is a ligand for the single member of a killer cell lectin-like receptor family, KLRH1.
Title: Identification of an MHC class I ligand for the single member of a killer cell lectin-like receptor family, KLRH1.
The MHC haplotype of the host appears to influence Klrh1 expression, suggesting that it may function as an MHC-binding receptor on subsets of NK cells and T lymphocytes.
Title: Characterization of a novel killer cell lectin-like receptor (KLRH1) expressed by alloreactive rat NK cells.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables (1->3)-beta-D-glucan binding	IEA Inferred from Electronic Annotation more info
enables antigen binding	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to molecule of fungal origin	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
involved_in stimulatory C-type lectin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: killer cell lectin-like receptor subfamily H, member 1

Names: killer cell lectin-like receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139187.2 → NP_631926.1 killer cell lectin-like receptor subfamily H, member 1

See identical proteins and their annotated locations for NP_631926.1

Status: PROVISIONAL

Source sequence(s)

AF416564

UniProtKB/TrEMBL

A0A0G2K314, Q8K4F1

Related

ENSRNOP00000072464.3, ENSRNOT00000079813.3

Conserved Domains (2) summary

cd03593
Location:104 → 220

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

pfam08391
Location:36 → 118

Ly49; Ly49-like protein, N-terminal region