Ndufs6 NADH:ubiquinone oxidoreductase subunit S6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ndufs6provided by RGD
Official Full Name: NADH:ubiquinone oxidoreductase subunit S6provided by RGD
Primary source: RGD:1584802
See related: EnsemblRapid:ENSRNOG00000062531 AllianceGenome:RGD:1584802
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ndufs6l1
Summary: Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to act upstream of or within several processes, including DNA damage response, signal transduction by p53 class mediator; mesenchymal stem cell proliferation; and mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in cervical cancer and nuclear type mitochondrial complex I deficiency 9. Orthologous to human NDUFS6 (NADH:ubiquinone oxidoreductase subunit S6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 1858.4), Muscle (RPKM 1129.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (31797400..31805965)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (29968833..29977423)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (32573204..32581785)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular senescence	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within circulatory system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesenchymal stem cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesenchymal stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial electron transport, NADH to ubiquinone	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitochondrial respiratory chain complex I assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrion organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within reproductive system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within respiratory electron transport chain	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within stem cell division	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex I	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

Names: NADH dehydrogenase (ubiquinone) Fe-S protein 6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial-like; NADH:ubiquinone oxidoreductase subunit S6-like 1

NP_001410618.1

EC 1.6.5.3

EC 1.6.99.3

EC 7.1.1.2

XP_063129356.1

EC 1.6.5.3

EC 1.6.99.3

EC 7.1.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001423689.1 → NP_001410618.1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P52504

UniProtKB/TrEMBL

A6I4Z8, A6JUY2

Related

ENSRNOP00000036045.3, ENSRNOT00000028988.4