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    Fat3 FAT atypical cadherin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 191571, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fat3provided by RGD
    Official Full Name
    FAT atypical cadherin 3provided by RGD
    Primary source
    RGD:620657
    See related
    EnsemblRapid:ENSRNOG00000011585 AllianceGenome:RGD:620657
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in cell-cell adhesion. Predicted to act upstream of or within generation of neurons; negative regulation of dendrite development; and retina layer formation. Predicted to be located in dendrite. Orthologous to human FAT3 (FAT atypical cadherin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 107.4), Kidney (RPKM 29.0) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fat3 in Genome Data Viewer
    Location:
    8q12
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (20972840..21555679, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (12691470..13274336, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (14417039..15011596, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479966 Neighboring gene melatonin receptor 1B Neighboring gene uncharacterized LOC102553833 Neighboring gene mortality factor 4 like 1, pseudogene 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mammalian fat3: a large protein that contains multiple cadherin and EGF-like motifs. Mitsui K, et al. Biochem Biophys Res Commun, 2002 Feb 1. PMID 11811999
    2. Control of neuronal morphology by the atypical cadherin Fat3. Deans MR, et al. Neuron, 2011 Sep 8. PMID 21903076, Free PMC Article
    3. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell morphogenesis involved in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell morphogenesis involved in neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dendrite development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of dendrite development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in interneuron migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within interneuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of dendrite development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of dendrite development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retina layer formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within retina layer formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protocadherin Fat 3
    Names
    FAT tumor suppressor homolog 3
    Fta3 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001413472.1 → NP_001400401.1  protocadherin Fat 3 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6ABM1
      Related
      ENSRNOP00000112730.1, ENSRNOT00000173686.1

    2. NM_138544.1 → NP_612553.1  protocadherin Fat 3 isoform 2 precursor

      See identical proteins and their annotated locations for NP_612553.1

      Status: PROVISIONAL

      Source sequence(s)
      AB076401
      UniProtKB/Swiss-Prot
      Q8R508
      Related
      ENSRNOP00000089392.2, ENSRNOT00000118830.2
      Conserved Domains (4) summary
      cd11304
      Location:1048 → 1143
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:285 → 363
      CA; Cadherin repeats
      cd00054
      Location:4097 → 4132
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam02210
      Location:3864 → 3993
      Laminin_G_2; Laminin G domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      20972840..21555679 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080778.2 → XP_038936706.1  protocadherin Fat 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AQQ4
      Related
      ENSRNOP00000096648.1, ENSRNOT00000109404.2
      Conserved Domains (4) summary
      cd11304
      Location:1048 → 1143
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:285 → 363
      CA; Cadherin repeats
      cd00054
      Location:4120 → 4155
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam02210
      Location:3887 → 4016
      Laminin_G_2; Laminin G domain

    2. XM_039080781.2 → XP_038936709.1  protocadherin Fat 3 isoform X3

      UniProtKB/TrEMBL
      F1LMF4
      Conserved Domains (4) summary
      cd11304
      Location:1048 → 1143
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:285 → 363
      CA; Cadherin repeats
      cd00054
      Location:4097 → 4132
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam02210
      Location:3864 → 3993
      Laminin_G_2; Laminin G domain

    3. XM_039080780.2 → XP_038936708.1  protocadherin Fat 3 isoform X2

      Related
      ENSRNOP00000015976.6, ENSRNOT00000015977.7
      Conserved Domains (4) summary
      cd11304
      Location:1048 → 1143
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:285 → 363
      CA; Cadherin repeats
      cd00054
      Location:4120 → 4155
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam02210
      Location:3887 → 4016
      Laminin_G_2; Laminin G domain

    4. XM_039080782.1 → XP_038936710.1  protocadherin Fat 3 isoform X3

      UniProtKB/TrEMBL
      F1LMF4
      Conserved Domains (4) summary
      cd11304
      Location:1048 → 1143
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:285 → 363
      CA; Cadherin repeats
      cd00054
      Location:4097 → 4132
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam02210
      Location:3864 → 3993
      Laminin_G_2; Laminin G domain

    5. XM_039080783.2 → XP_038936711.1  protocadherin Fat 3 isoform X4

      Conserved Domains (3) summary
      cd11304
      Location:2107 → 2203
      Cadherin_repeat; Cadherin tandem repeat domain
      cd00054
      Location:2964 → 2999
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam02210
      Location:2731 → 2860
      Laminin_G_2; Laminin G domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R508.1 GenPept UniProtKB/Swiss-Prot:Q8R508

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