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    Klra5 killer cell lectin-like receptor, subfamily A, member 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297666, updated on 9-Dec-2024

    Summary

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    Symbol
    Klra5provided by RGD
    Full Name
    killer cell lectin-like receptor, subfamily A, member 5provided by RGD
    Primary source
    RGD:735134
    See related
    EnsemblRapid:ENSRNOG00000061664 AllianceGenome:RGD:735134
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ly-49.9
    Summary
    Predicted to enable signaling receptor activity. Predicted to be involved in regulation of signal transduction. Predicted to be located in plasma membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 28.0), Lung (RPKM 17.4) and 7 other tissues See more
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    Genomic context

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    See Klra5 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (166491210..166556087, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (164761839..164824367, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (165169417..165317573, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene Ly49 stimulatory receptor 8 Neighboring gene peptidyl-prolyl cis-trans isomerase D pseudogene Neighboring gene killer cell lectin-like receptor 4 Neighboring gene Ly49 stimulatory receptor 7 Neighboring gene Ly49 inhibitory receptor 7 Neighboring gene killer cell lectin-like receptor, subfamily A, member 2 Neighboring gene uncharacterized LOC108350878

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. An autosomal dominant locus, Nka, mapping to the Ly-49 region of a rat natural killer (NK) gene complex, controls NK cell lysis of allogeneic lymphocytes. Dissen E, et al. J Exp Med, 1996 May 1. PMID 8642329, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    killer cell lectin-like receptor, subfamily A, member 5
    Names
    Ly-49.9 antigen
    killer cell lectin-like receptor 5
    killer cell lectin-like receptor 5-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198746.4 → NP_942041.3  killer cell lectin-like receptor, subfamily A, member 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IM90, E9PTN0, Q62982
      Related
      ENSRNOP00000065392.3, ENSRNOT00000073877.3
      Conserved Domains (2) summary
      cd03593
      Location:145 → 260
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:40 → 157
      Ly49; Ly49-like protein, N-terminal region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      166491210..166556087 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285916.1 → XP_063141986.1  killer cell lectin-like receptor, subfamily A, member 5 isoform X2

      UniProtKB/TrEMBL
      Q62982

    2. XM_039107455.2 → XP_038963383.1  killer cell lectin-like receptor, subfamily A, member 5 isoform X1

      Related
      ENSRNOP00000069231.4, ENSRNOT00000087529.4
      Conserved Domains (2) summary
      cd03593
      Location:211 → 326
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:106 → 223
      Ly49; Ly49-like protein, N-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version

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