Letm1 leucine zipper and EF-hand containing transmembrane protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Letm1provided by RGD
Official Full Name: leucine zipper and EF-hand containing transmembrane protein 1provided by RGD
Primary source: RGD:1359678
See related: EnsemblRapid:ENSRNOG00000016427 AllianceGenome:RGD:1359678
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: KHE
Summary: Predicted to enable calcium:proton antiporter activity. Predicted to be involved in several processes, including cristae formation; monoatomic cation transmembrane transport; and protein complex oligomerization. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Orthologous to human LETM1 (leucine zipper and EF-hand containing transmembrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 243.6), Heart (RPKM 165.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (81167268..81206776)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (76942647..76982220)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (82227790..82267298)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Letm1 expression is decreased in patients with intractable TLE and a rat model of epilepsy. Down-regulation of Letm1 leads to increases mitochondrial swelling and decreased MT-CYB expression, which is associated with susceptibility to seizures.
Title: Association of mitochondrial letm1 with epileptic seizures.
Reconstitution of LETM1 or antioxidant overexpression rescued mitochondrial Ca(2+) transport and bioenergetics
Title: LETM1-dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium:proton antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium:proton antiporter activity	IEA Inferred from Electronic Annotation more info
enables calcium:proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables calcium:proton antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ribosome binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium export from the mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in calcium export from the mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in calcium export from the mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in cristae formation	IEA Inferred from Electronic Annotation more info
involved_in cristae formation	ISO Inferred from Sequence Orthology more info
involved_in inner mitochondrial membrane organization	ISO Inferred from Sequence Orthology more info
involved_in inner mitochondrial membrane organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial calcium ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial calcium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrion organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of mitochondrial calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mitochondrial calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein hexamerization	IEA Inferred from Electronic Annotation more info
involved_in protein hexamerization	ISO Inferred from Sequence Orthology more info
involved_in protein hexamerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of cellular hyperosmotic salinity response	IEA Inferred from Electronic Annotation more info
involved_in regulation of cellular hyperosmotic salinity response	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular hyperosmotic salinity response	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial proton/calcium exchanger protein

Names: LETM1 and EF-hand domain-containing protein 1, mitochondrial; electroneutral mitochondrial K(+)/H(+)exchanger; leucine zipper-EF-hand-containing transmembrane protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005884.1 → NP_001005884.1 mitochondrial proton/calcium exchanger protein precursor

See identical proteins and their annotated locations for NP_001005884.1

Status: PROVISIONAL

Source sequence(s)

BC083642

UniProtKB/Swiss-Prot

Q5XIN6

UniProtKB/TrEMBL

A0A8I5ZLQ4, A6IK50

Related

ENSRNOP00000022540.3, ENSRNOT00000022540.8

Conserved Domains (2) summary

pfam07766
Location:152 → 416

LETM1; LETM1-like protein

NF033930
Location:418 → 592

pneumo_PspA; pneumococcal surface protein A