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    Nrbp1 nuclear receptor binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 619579, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nrbp1provided by RGD
    Official Full Name
    nuclear receptor binding protein 1provided by RGD
    Primary source
    RGD:1589575
    See related
    EnsemblRapid:ENSRNOG00000050570 AllianceGenome:RGD:1589575
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nrbp
    Summary
    Predicted to enable protein homodimerization activity. Predicted to be involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; epithelial cell proliferation; and in utero embryonic development. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytoplasm and endomembrane system. Orthologous to human NRBP1 (nuclear receptor binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 230.4), Muscle (RPKM 228.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nrbp1 in Genome Data Viewer
    Location:
    6q14
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (30842606..30853177, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (25122635..25133209, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (26486823..26497396, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain containing 4 Neighboring gene intraflagellar transport 172 Neighboring gene keratinocyte associated protein 3 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1G Neighboring gene zinc finger protein 513

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain. De Langhe S, et al. Int J Mol Med, 2002 May. PMID 11956649
    2. MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1. Lim R, et al. J Biol Chem, 2002 Oct 25. PMID 12176995
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endomembrane system ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nuclear receptor-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034997.1 → NP_001030169.1  nuclear receptor-binding protein

      See identical proteins and their annotated locations for NP_001030169.1

      Status: PROVISIONAL

      Source sequence(s)
      BC104694
      UniProtKB/TrEMBL
      M0RCC7, Q3SWT7
      Related
      ENSRNOP00000083137.1, ENSRNOT00000108698.2
      Conserved Domains (1) summary
      cd14034
      Location:60 → 334
      PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      30842606..30853177 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594340.3 → XP_017449829.1  nuclear receptor-binding protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6GDA0, M0RCC7
      Related
      ENSRNOP00000085375.1, ENSRNOT00000109359.2
      Conserved Domains (1) summary
      cd14034
      Location:60 → 342
      PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1
    Nucleotide Protein Strain
    Heading Accession and Version

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