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    Agl amylo-alpha-1,6-glucosidase and 4-alpha-glucanotransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362029, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aglprovided by RGD
    Official Full Name
    amylo-alpha-1,6-glucosidase and 4-alpha-glucanotransferaseprovided by RGD
    Primary source
    RGD:1306376
    See related
    EnsemblRapid:ENSRNOG00000016214 AllianceGenome:RGD:1306376
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables 4-alpha-glucanotransferase activity; amylo-alpha-1,6-glucosidase activity; and carbohydrate binding activity. Involved in glycogen catabolic process; response to glucocorticoid; and response to nutrient. Located in sarcoplasmic reticulum. Used to study uremia. Human ortholog(s) of this gene implicated in glycogen storage disease III. Orthologous to human AGL (amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 1109.1), Heart (RPKM 209.7) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Agl in Genome Data Viewer
    Location:
    2q42
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (207389949..207445959, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (204705053..204760966, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (219788234..219843189, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase 13 homolog Neighboring gene SAS-6 centriolar assembly protein Neighboring gene major facilitator superfamily domain containing 14A Neighboring gene uncharacterized LOC102548510 Neighboring gene solute carrier family 35 member A3 Neighboring gene uncharacterized LOC120100926 Neighboring gene uncharacterized LOC102548573 Neighboring gene ferric-chelate reductase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hepatic and neuromuscular forms of glycogenosis type III: nine mutations in AGL. Lucchiari S, et al. Hum Mutat, 2006 Jun. PMID 16705713
    2. Glycogen debranching enzyme is associated with rat skeletal muscle sarcoplasmic reticulum. Lees SJ, et al. Acta Physiol Scand, 2004 Jun. PMID 15180797
    3. N-methyl-1-deoxynojirimycin (MOR-14), an alpha-glucosidase inhibitor, markedly improves postischemic left ventricular dysfunction. Nishida Y, et al. Heart Vessels, 2000. PMID 11766064
    4. Inhibition of glycogenolysis by a glucose analogue in the working rat heart. Depre C, et al. J Mol Cell Cardiol, 1997 Aug. PMID 9281456
    5. [Effect of biogenic amines on glycogen degradation in isolated rat hepatocytes]. Popova IA, et al. Vopr Med Khim, 1992 Mar-Apr. PMID 1413626

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 4-alpha-glucanotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4-alpha-glucanotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 4-alpha-glucanotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables amylo-alpha-1,6-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amylo-alpha-1,6-glucosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables amylo-alpha-1,6-glucosidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carbohydrate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycogen debranching enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables polysaccharide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycogen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycogen catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycogen catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycogen catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within glycogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to glucocorticoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to hormone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to nutrient IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in inclusion body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glycogen debranching enzyme
    Names
    amylo-1, 6-glucosidase, 4-alpha-glucanotransferase (glycogen debranching enzyme, glycogen storage disease type III)
    amylo-1,6-glucosidase, 4-alpha-glucanotransferase
    amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
    NP_001102034.1
    XP_006233291.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108564.1 → NP_001102034.1  glycogen debranching enzyme

      See identical proteins and their annotated locations for NP_001102034.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473952
      UniProtKB/TrEMBL
      A6HVA9, D4AEH9
      Related
      ENSRNOP00000052593.2, ENSRNOT00000055735.4
      Conserved Domains (5) summary
      cd11327
      Location:105 → 583
      AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes
      TIGR01531
      Location:22 → 1532
      glyc_debranch; glycogen debranching enzymye
      pfam06202
      Location:1073 → 1527
      GDE_C; Amylo-alpha-1,6-glucosidase
      pfam14699
      Location:31 → 116
      hGDE_N; N-terminal domain from the human glycogen debranching enzyme
      pfam14702
      Location:697 → 974
      hGDE_central; central domain of human glycogen debranching enzyme

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      207389949..207445959 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233229.5 → XP_006233291.1  glycogen debranching enzyme isoform X1

      See identical proteins and their annotated locations for XP_006233291.1

      UniProtKB/TrEMBL
      A6HVA9, D4AEH9
      Conserved Domains (5) summary
      cd11327
      Location:105 → 583
      AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes
      TIGR01531
      Location:22 → 1532
      glyc_debranch; glycogen debranching enzymye
      pfam06202
      Location:1073 → 1527
      GDE_C; Amylo-alpha-1,6-glucosidase
      pfam14699
      Location:31 → 116
      hGDE_N; N-terminal domain from the human glycogen debranching enzyme
      pfam14702
      Location:697 → 974
      hGDE_central; central domain of human glycogen debranching enzyme
    Nucleotide Protein Strain
    Heading Accession and Version

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