Kdelr3 KDEL endoplasmic reticulum protein retention receptor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kdelr3provided by RGD
Official Full Name: KDEL endoplasmic reticulum protein retention receptor 3provided by RGD
Primary source: RGD:1311536
See related: AllianceGenome:RGD:1311536
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable KDEL sequence binding activity. Predicted to be involved in protein retention in ER lumen and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in COPI-coated vesicle membrane; Golgi membrane; and endoplasmic reticulum membrane. Predicted to be active in cis-Golgi network and endoplasmic reticulum. Orthologous to human KDELR3 (KDEL endoplasmic reticulum protein retention receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 184.0), Heart (RPKM 132.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (112959632..112969858)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (111079236..111089463)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (120749680..120760163)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH127676 (e-PCR)
- UniSTS:210986

C80929 (e-PCR)
- UniSTS:160470

D7Rat12 (e-PCR)
- UniSTS:119017

AA819656 (e-PCR)
- UniSTS:243451

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ER retention sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables KDEL sequence binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in protein retention in ER lumen	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in COPI-coated vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
is_active_in cis-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ER lumen protein-retaining receptor 3

Names: KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127546.1 → NP_001121018.1 ER lumen protein-retaining receptor 3

See identical proteins and their annotated locations for NP_001121018.1

Status: PROVISIONAL

Source sequence(s)

BC162033

UniProtKB/TrEMBL

B1WC77, F1LPB5

Conserved Domains (1) summary

pfam00810
Location:28 → 169

ER_lumen_recept; ER lumen protein retaining receptor