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    Prodh proline dehydrogenase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680409, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prodhprovided by RGD
    Official Full Name
    proline dehydrogenaseprovided by RGD
    Primary source
    RGD:1590932
    See related
    EnsemblRapid:ENSRNOG00000000281 AllianceGenome:RGD:1590932
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Prodh1
    Summary
    Enables amino acid binding activity and proline dehydrogenase activity. Predicted to be involved in proline catabolic process to glutamate and regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in amino acid metabolic disorder; hyperprolinemia type 1; and schizophrenia 4. Orthologous to human PRODH (proline dehydrogenase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 361.7), Heart (RPKM 180.2) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prodh in Genome Data Viewer
    Location:
    11q23
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (96414275..96431604)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (82910043..82927305)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (87058478..87075785)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555338 Neighboring gene reticulon 4 receptor Neighboring gene DiGeorge syndrome critical region gene 6 Neighboring gene V-set pre-B cell surrogate light chain 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. [Necrotizing scleritis--successful treatment with solcoseryl]. Dabrowska A. Klin Oczna, 1992 Jul-Aug. PMID 1300406
    2. Functional consequences of PRODH missense mutations. Bender HU, et al. Am J Hum Genet, 2005 Mar. PMID 15662599, Free PMC Article
    3. The severe form of type I hyperprolinaemia results from homozygous inactivation of the PRODH gene. Jacquet H, et al. J Med Genet, 2003 Jan. PMID 12525555, Free PMC Article
    4. Mechanism-based inhibition of proline dehydrogenase by proline analogues. Tritsch D, et al. Biochim Biophys Acta, 1993 Sep 3. PMID 8373828
    5. PRODH mutations and hyperprolinemia in a subset of schizophrenic patients. Jacquet H, et al. Hum Mol Genet, 2002 Sep 15. PMID 12217952

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables FAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables FAD binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables amino acid binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables proline dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proline dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables proline dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in proline catabolic process to glutamate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    proline dehydrogenase 1, mitochondrial
    Names
    proline dehydrogenase (oxidase) 1
    proline dehydrogenase (proline oxidase)
    proline dehydrogenase, mitochondrial
    NP_001129250.3
    XP_006248704.5
    XP_006248705.2
    XP_008767125.2
    XP_063126832.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135778.3 → NP_001129250.3  proline dehydrogenase 1, mitochondrial isoform 4

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000011
      Conserved Domains (1) summary
      PLN02681
      Location:47 → 594
      PLN02681; proline dehydrogenase

    2. NM_001431659.1 → NP_001418588.1  proline dehydrogenase 1, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      F1MAR6

    3. NM_001431660.1 → NP_001418589.1  proline dehydrogenase 1, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A6JSI7

    4. NM_001431661.1 → NP_001418590.1  proline dehydrogenase 1, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A0G2K2S1, A6JSI7

    RNA

    1. NR_197240.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      96414275..96431604
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008768903.4 → XP_008767125.2  proline dehydrogenase 1, mitochondrial isoform X4

      Conserved Domains (1) summary
      PLN02681
      Location:3 → 492
      PLN02681; proline dehydrogenase

    2. XM_006248642.5 → XP_006248704.5  proline dehydrogenase 1, mitochondrial isoform X1

      Related
      ENSRNOP00000002576.8, ENSRNOT00000002576.9

    3. XM_063270762.1 → XP_063126832.1  proline dehydrogenase 1, mitochondrial isoform X2

      Related
      ENSRNOP00000100179.1, ENSRNOT00000126432.1

    4. XM_006248643.4 → XP_006248705.2  proline dehydrogenase 1, mitochondrial isoform X3

      Related
      ENSRNOP00000072350.2, ENSRNOT00000082855.3
      Conserved Domains (1) summary
      PLN02681
      Location:19 → 533
      PLN02681; proline dehydrogenase

    RNA

    1. XR_005491055.2 RNA Sequence

    2. XR_005491056.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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