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    Tbpl1 TATA-box binding protein like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689030, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tbpl1provided by RGD
    Official Full Name
    TATA-box binding protein like 1provided by RGD
    Primary source
    RGD:1597456
    See related
    EnsemblRapid:ENSRNOG00000066988 AllianceGenome:RGD:1597456
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA polymerase II core promoter sequence-specific DNA binding activity and RNA polymerase II general transcription initiation factor activity. Predicted to be involved in DNA-templated transcription initiation. Predicted to act upstream of or within acrosome assembly; dTTP biosynthetic process; and spermatid nucleus differentiation. Predicted to be located in cytoplasm and male germ cell nucleus. Predicted to be part of transcription factor TFIIA complex. Orthologous to human TBPL1 (TATA-box binding protein like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 443.4), Brain (RPKM 197.5) and 9 other tissues See more
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    Genomic context

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    See Tbpl1 in Genome Data Viewer
    Location:
    1p12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (24597028..24622445)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (22777892..22803305)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (23977154..24002512)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transcription factor 21 Neighboring gene uncharacterized LOC120098885 Neighboring gene solute carrier family 2 member 12 Neighboring gene uncharacterized LOC102555830

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Involvement of reactive oxygen species and TATA box-binding protein-related factor 2 in testicular torsion/detorsion-induced injury. Wei SM, et al. Urology, 2013 Feb. PMID 23374846
    2. Distinct functions of TBP and TLF/TRF2 during spermatogenesis: requirement of TLF for heterochromatic chromocenter formation in haploid round spermatids. Martianov I, et al. Development, 2002 Feb. PMID 11861477
    3. TIPT, a male germ cell-specific partner of TRF2, is chromatin-associated and interacts with HP1. Brancorsini S, et al. Cell Cycle, 2008 May 15. PMID 18418073
    4. TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP. Chong JA, et al. Mol Cell Biol, 2005 Apr. PMID 15767669, Free PMC Article
    5. Changes in intranuclear chromatin architecture induce bipolar nuclear localization of histone variant H1T2 in male haploid spermatids. Catena R, et al. Dev Biol, 2006 Aug 1. PMID 16765935

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings have indicated that overproduction of reactive oxygen species after testicular torsion-detorsion can damage testicular spermatogenesis by downregulation of TRF2 expression.
      Title: Involvement of reactive oxygen species and TATA box-binding protein-related factor 2 in testicular torsion/detorsion-induced injury.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II core promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within acrosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within dTTP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatid nucleus differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in male germ cell nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIIA complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TATA box-binding protein-like 1
    Names
    TATA box-binding protein-like protein 1
    TBP-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127201.1 → NP_001120673.1  TATA box-binding protein-like 1

      See identical proteins and their annotated locations for NP_001120673.1

      Status: VALIDATED

      Source sequence(s)
      AW434020, BF414163, CF109177
      UniProtKB/TrEMBL
      A0A8I6A122
      Conserved Domains (1) summary
      cd04517
      Location:9 → 180
      TLF; TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      24597028..24622445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274478.1 → XP_063130548.1  TATA box-binding protein-like 1 isoform X1

    2. XM_063274508.1 → XP_063130578.1  TATA box-binding protein-like 1 isoform X5

    3. XM_063274545.1 → XP_063130615.1  TATA box-binding protein-like 1 isoform X9

    4. XM_063274480.1 → XP_063130550.1  TATA box-binding protein-like 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AM51
      Related
      ENSRNOP00000094712.1, ENSRNOT00000115485.2

    5. XM_063274511.1 → XP_063130581.1  TATA box-binding protein-like 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I6A122

    6. XM_039091317.1 → XP_038947245.1  TATA box-binding protein-like 1 isoform X8

      Conserved Domains (1) summary
      cl08263
      Location:1 → 164
      TBP_TLF; TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: ...

    7. XM_063274492.1 → XP_063130562.1  TATA box-binding protein-like 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AM51

    8. XM_063274495.1 → XP_063130565.1  TATA box-binding protein-like 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AM51

    9. XM_039091288.2 → XP_038947216.1  TATA box-binding protein-like 1 isoform X2

      Conserved Domains (1) summary
      cd04517
      Location:41 → 232
      TLF; TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the ...

    10. XM_039091312.2 → XP_038947240.1  TATA box-binding protein-like 1 isoform X6

      Conserved Domains (1) summary
      cd04517
      Location:41 → 200
      TLF; TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the ...

    11. XM_039091315.1 → XP_038947243.1  TATA box-binding protein-like 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I6A122
      Conserved Domains (1) summary
      cd04517
      Location:9 → 180
      TLF; TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the ...

    12. XM_063274512.1 → XP_063130582.1  TATA box-binding protein-like 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I6A122
      Related
      ENSRNOP00000084884.1, ENSRNOT00000116875.2

    13. XM_063274513.1 → XP_063130583.1  TATA box-binding protein-like 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I6A122

    14. XM_017589742.2 → XP_017445231.1  TATA box-binding protein-like 1 isoform X4

      Related
      ENSRNOP00000014805.6, ENSRNOT00000014805.9
      Conserved Domains (1) summary
      cd04517
      Location:9 → 212
      TLF; TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the ...

    15. XM_063274520.1 → XP_063130590.1  TATA box-binding protein-like 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I6A122

    16. XM_063274486.1 → XP_063130556.1  TATA box-binding protein-like 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AM51
    Nucleotide Protein Strain
    Heading Accession and Version

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