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    Ark2c arkadia C-terminal like ring finger ubiquitin ligase 2C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307251, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ark2cprovided by RGD
    Official Full Name
    arkadia C-terminal like ring finger ubiquitin ligase 2Cprovided by RGD
    Primary source
    RGD:1560744
    See related
    EnsemblRapid:ENSRNOG00000048824 AllianceGenome:RGD:1560744
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rnf165; RGD1560744
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in motor neuron axon guidance and positive regulation of BMP signaling pathway. Predicted to act upstream of or within several processes, including forelimb morphogenesis; nervous system development; and protein polyubiquitination. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Orthologous to human ARK2C (arkadia (RNF111) C-terminal like ring finger ubiquitin ligase 2C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 21.4), Adrenal (RPKM 3.3) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ark2c in Genome Data Viewer
    Location:
    18q12.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (73259736..73375987, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (70984566..71100836, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (73831289..73873246, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551787 Neighboring gene lipoxygenase homology PLAT domains 1 Neighboring gene uncharacterized protein DDB_G0292186-like Neighboring gene uncharacterized LOC108348739 Neighboring gene uncharacterized LOC102551968

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. Kelly CE, et al. PLoS Biol, 2013. PMID 23610558, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within axonogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within forelimb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within innervation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within limb development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in motor neuron axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within motor neuron axon guidance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within muscle structure development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase ARK2C
    Names
    E3 ubiquitin-protein ligase RNF165
    ring finger protein 165
    NP_001157977.1
    XP_038952706.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164505.2 → NP_001157977.1  E3 ubiquitin-protein ligase ARK2C

      See identical proteins and their annotated locations for NP_001157977.1

      Status: VALIDATED

      Source sequence(s)
      BC166566
      UniProtKB/TrEMBL
      A0A8I5ZSL4, B2GV81, M0RCK2
      Related
      ENSRNOP00000067322.2, ENSRNOT00000075580.4
      Conserved Domains (2) summary
      pfam07573
      Location:30 → 84
      AreA_N; Nitrogen regulatory protein AreA N terminus
      pfam13639
      Location:296 → 337
      zf-RING_2; Ring finger domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      73259736..73375987 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096778.2 → XP_038952706.1  E3 ubiquitin-protein ligase ARK2C isoform X1

      UniProtKB/TrEMBL
      A6KMV1
      Conserved Domains (1) summary
      cd16474
      Location:227 → 272
      RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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