Gnpda2 glucosamine-6-phosphate deaminase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gnpda2provided by RGD
Official Full Name: glucosamine-6-phosphate deaminase 2provided by RGD
Primary source: RGD:1305521
See related: EnsemblRapid:ENSRNOG00000002177 AllianceGenome:RGD:1305521
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable glucosamine-6-phosphate deaminase activity and identical protein binding activity. Predicted to be involved in N-acetylneuraminate catabolic process; UDP-N-acetylglucosamine biosynthetic process; and glucosamine-containing compound catabolic process. Predicted to be active in cytoplasm. Orthologous to human GNPDA2 (glucosamine-6-phosphate deaminase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 160.1), Lung (RPKM 99.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (38874611..38892688)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (38520663..38538713)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (62628102..62646158, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Long-Evans rats maintained on chow or a high-fat diet (HFD) for 6 weeks. From a total of 19 genes analyzed, seven genes (ETV5, FTO, GNPDA2, KCTD15, TMEM18, MC4R, and SH2B1) were down-regulated in the hypothalamus of HFD compared to chow-fed rats
Title: Expression of new loci associated with obesity in diet-induced obese rats: from genetics to physiology.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129612 (e-PCR)
- UniSTS:212910

RH142376 (e-PCR)
- UniSTS:231623

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glucosamine-6-phosphate deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucosamine-6-phosphate deaminase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-acetylglucosamine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in N-acetylneuraminate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in UDP-N-acetylglucosamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in UDP-N-acetylglucosamine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glucosamine catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glucosamine-6-phosphate isomerase 2

NP_001099475.1

EC 3.5.99.6

XP_006251098.1

EC 3.5.99.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106005.1 → NP_001099475.1 glucosamine-6-phosphate isomerase 2

See identical proteins and their annotated locations for NP_001099475.1

Status: PROVISIONAL

Source sequence(s)

CH473981

UniProtKB/TrEMBL

B5DEZ6, F7FL82

Conserved Domains (1) summary

cl00339
Location:1 → 253

SugarP_isomerase; Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

38874611..38892688

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006251036.5 → XP_006251098.1 glucosamine-6-phosphate isomerase 2 isoform X1

Related

ENSRNOP00000002992.5, ENSRNOT00000002992.8

Conserved Domains (1) summary

cl00339
Location:1 → 251

SugarP_isomerase; Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose ...