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    Ing4 inhibitor of growth family, member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297597, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ing4provided by RGD
    Official Full Name
    inhibitor of growth family, member 4provided by RGD
    Primary source
    RGD:1309407
    See related
    EnsemblRapid:ENSRNOG00000023363 AllianceGenome:RGD:1309407
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable methylated histone binding activity and transcription coactivator activity. Predicted to contribute to histone acetyltransferase activity. Predicted to be involved in several processes, including DNA replication-dependent chromatin disassembly; positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of with a negative effect on regulation of cell cycle G2/M phase transition. Predicted to be located in cytosol; intermediate filament cytoskeleton; and nucleoplasm. Predicted to be part of histone acetyltransferase complex. Predicted to be active in nucleus. Orthologous to human ING4 (inhibitor of growth family member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 188.7), Lung (RPKM 158.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ing4 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (159528183..159536762)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (157841882..157850519)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157554729..157563353)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene PILR alpha associated neural protein Neighboring gene zinc finger protein 384 Neighboring gene uncharacterized LOC102554095 Neighboring gene acrosin binding protein Neighboring gene lysophosphatidic acid receptor 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Inhibitor of growth 4 (ING4) is up-regulated by a low K intake and suppresses renal outer medullary K channels (ROMK) by MAPK stimulation. Zhang X, et al. Proc Natl Acad Sci U S A, 2007 May 29. PMID 17517644, Free PMC Article
    2. ING4 induces G2/M cell cycle arrest and enhances the chemosensitivity to DNA-damage agents in HepG2 cells. Zhang X, et al. FEBS Lett, 2004 Jul 16. PMID 15251430
    3. Mouse ING1 homologue, a protein interacting with A1, enhances cell death and is inhibited by A1 in mammary epithelial cells. Ha S, et al. Cancer Res, 2002 Mar 1. PMID 11888890
    4. The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis. Garkavtsev I, et al. Nature, 2004 Mar 18. PMID 15029197
    5. p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. Shiseki M, et al. Cancer Res, 2003 May 15. PMID 12750254

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. provide evidence for the role of ING4 in mediating the effect of low K intake on renal outer medullary K channel activity by stimulation of p38 and ERK mitogen-activated protein kinase
      Title: Inhibitor of growth 4 (ING4) is up-regulated by a low K intake and suppresses renal outer medullary K channels (ROMK) by MAPK stimulation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156688

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to histone H3K14 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to histone H4K12 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT contributes_to histone H4K16 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to histone H4K5 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to histone H4K8 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication-dependent chromatin disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_negative_effect regulation of cell cycle G2/M phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intermediate filament cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inhibitor of growth protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079887.1 → NP_001073356.1  inhibitor of growth protein 4

      See identical proteins and their annotated locations for NP_001073356.1

      Status: PROVISIONAL

      Source sequence(s)
      BC127511
      UniProtKB/TrEMBL
      A1L130, A6ILQ5, F1LLY0
      Conserved Domains (2) summary
      COG5034
      Location:7 → 241
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd16862
      Location:11 → 104
      ING_ING4; Inhibitor of growth (ING) domain of inhibitor of growth protein 4 (ING4)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      159528183..159536762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237349.5 → XP_006237411.1  inhibitor of growth protein 4 isoform X1

      UniProtKB/TrEMBL
      A6ILQ5
      Related
      ENSRNOP00000024116.8, ENSRNOT00000024116.8
      Conserved Domains (2) summary
      COG5034
      Location:7 → 245
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd16862
      Location:11 → 104
      ING_ING4; Inhibitor of growth (ING) domain of inhibitor of growth protein 4 (ING4)

    2. XM_006237350.5 → XP_006237412.1  inhibitor of growth protein 4 isoform X2

      UniProtKB/TrEMBL
      A6ILQ5
      Conserved Domains (2) summary
      COG5034
      Location:7 → 244
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd16862
      Location:11 → 104
      ING_ING4; Inhibitor of growth (ING) domain of inhibitor of growth protein 4 (ING4)

    3. XM_039107453.2 → XP_038963381.1  inhibitor of growth protein 4 isoform X3

      UniProtKB/TrEMBL
      A0A8J8YN55, A6ILQ5
      Conserved Domains (2) summary
      COG5034
      Location:7 → 242
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd16862
      Location:11 → 104
      ING_ING4; Inhibitor of growth (ING) domain of inhibitor of growth protein 4 (ING4)

    RNA

    1. XR_005503203.2 RNA Sequence

    2. XR_005503204.2 RNA Sequence

    3. XR_005503205.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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