Lrrc38 leucine rich repeat containing 38 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lrrc38provided by RGD
Official Full Name: leucine rich repeat containing 38provided by RGD
Primary source: RGD:1311416
See related: EnsemblRapid:ENSRNOG00000015264 AllianceGenome:RGD:1311416
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311416
Summary: Predicted to enable potassium channel activator activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Predicted to be involved in positive regulation of voltage-gated potassium channel activity and potassium ion transmembrane transport. Predicted to be part of voltage-gated potassium channel complex. Orthologous to human LRRC38 (leucine rich repeat containing 38). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 26.3) and Brain (RPKM 10.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (160968790..160990871)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (155685495..155707578)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (162031722..162053723)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables potassium channel activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel activator activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: leucine-rich repeat-containing protein 38

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107991.1 → NP_001101461.1 leucine-rich repeat-containing protein 38 precursor

See identical proteins and their annotated locations for NP_001101461.1

Status: PROVISIONAL

Source sequence(s)

CH473968

UniProtKB/TrEMBL

A6ITZ6, D3ZYA6

Related

ENSRNOP00000020483.5, ENSRNOT00000020483.9

Conserved Domains (5) summary

smart00013
Location:31 → 62

LRRNT; Leucine rich repeat N-terminal domain

cd00116
Location:49 → 190

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:42 → 64

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:133 → 191

LRR_8; Leucine rich repeat

cl15307
Location:190 → 244

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain