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    Slc39a11 solute carrier family 39, member 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287796, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc39a11provided by RGD
    Official Full Name
    solute carrier family 39, member 11provided by RGD
    Primary source
    RGD:1311981
    See related
    EnsemblRapid:ENSRNOG00000031213 AllianceGenome:RGD:1311981
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable copper ion transmembrane transporter activity and zinc ion transmembrane transporter activity. Predicted to be involved in zinc ion import across plasma membrane. Predicted to be located in Golgi apparatus; nucleus; and plasma membrane. Predicted to be active in membrane. Orthologous to human SLC39A11 (solute carrier family 39 member 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 55.3), Kidney (RPKM 25.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc39a11 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (98775155..99196302, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (98275958..98697042, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (101754842..102169100, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549836 Neighboring gene uncharacterized LOC134480896 Neighboring gene microRNA 297 Neighboring gene uncharacterized LOC134480897 Neighboring gene uncharacterized LOC120095210 Neighboring gene transfer RNA alanine (anticodon UGC) 10 Neighboring gene somatostatin receptor 2 Neighboring gene component of oligomeric golgi complex 1 Neighboring gene mitochondrial nucleoid associated protein 1 Neighboring gene VCP nuclear cofactor family member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Gastric and colonic zinc transporter ZIP11 (Slc39a11) in mice responds to dietary zinc and exhibits nuclear localization. Martin AB, et al. J Nutr, 2013 Dec. PMID 24089422, Free PMC Article
    2. Mapping the zinc-transporting system in mammary cells: molecular analysis reveals a phenotype-dependent zinc-transporting network during lactation. Kelleher SL, et al. J Cell Physiol, 2012 Apr. PMID 21702047, Free PMC Article
    3. Characterization of the GufA subfamily member SLC39A11/Zip11 as a zinc transporter. Yu Y, et al. J Nutr Biochem, 2013 Oct. PMID 23643525
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables copper ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables copper ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables copper ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in copper ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in zinc ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in zinc ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc transporter ZIP11
    Names
    ZIP-11
    solute carrier family 39 (metal ion transporter), member 11
    zrt- and Irt-like protein 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013042.2 → NP_001013060.1  zinc transporter ZIP11

      See identical proteins and their annotated locations for NP_001013060.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q6P6S2
      Conserved Domains (1) summary
      COG0428
      Location:6 → 335
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      98775155..99196302 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268767.1 → XP_063124837.1  zinc transporter ZIP11 isoform X7

    2. XM_039085657.2 → XP_038941585.1  zinc transporter ZIP11 isoform X6

      Conserved Domains (1) summary
      COG0428
      Location:1 → 292
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    3. XM_063268766.1 → XP_063124836.1  zinc transporter ZIP11 isoform X5

      UniProtKB/Swiss-Prot
      Q6P6S2

    4. XM_006247670.5 → XP_006247732.1  zinc transporter ZIP11 isoform X4

      See identical proteins and their annotated locations for XP_006247732.1

      Conserved Domains (1) summary
      COG0428
      Location:6 → 342
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    5. XM_017597148.3 → XP_017452637.1  zinc transporter ZIP11 isoform X4

      Conserved Domains (1) summary
      COG0428
      Location:6 → 342
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    6. XM_006247668.5 → XP_006247730.1  zinc transporter ZIP11 isoform X4

      See identical proteins and their annotated locations for XP_006247730.1

      Conserved Domains (1) summary
      COG0428
      Location:6 → 342
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    7. XM_039085656.2 → XP_038941584.1  zinc transporter ZIP11 isoform X4

      Related
      ENSRNOP00000098332.1, ENSRNOT00000120701.2
      Conserved Domains (1) summary
      COG0428
      Location:6 → 342
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    8. XM_039085655.2 → XP_038941583.1  zinc transporter ZIP11 isoform X2

      Conserved Domains (1) summary
      COG0428
      Location:23 → 359
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    9. XM_063268765.1 → XP_063124835.1  zinc transporter ZIP11 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZZC3

    10. XM_006247664.5 → XP_006247726.1  zinc transporter ZIP11 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QK09
      Related
      ENSRNOP00000098333.2, ENSRNOT00000120702.2
      Conserved Domains (1) summary
      COG0428
      Location:38 → 374
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    11. XM_039085660.2 → XP_038941588.1  zinc transporter ZIP11 isoform X10

      Conserved Domains (1) summary
      COG0428
      Location:37 → 204
      ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

    12. XM_039085659.2 → XP_038941587.2  zinc transporter ZIP11 isoform X9

    13. XM_039085658.2 → XP_038941586.1  zinc transporter ZIP11 isoform X8

      Conserved Domains (1) summary
      cl00437
      Location:6 → 114
      Zip; ZIP Zinc transporter
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P6S2.1 GenPept UniProtKB/Swiss-Prot:Q6P6S2

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