Suz12 SUZ12 polycomb repressive complex 2 subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Suz12provided by RGD
Official Full Name: SUZ12 polycomb repressive complex 2 subunitprovided by RGD
Primary source: RGD:1593621
See related: EnsemblRapid:ENSRNOG00000058663 AllianceGenome:RGD:1593621
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including nucleic acid binding activity; promoter-specific chromatin binding activity; and transcription corepressor binding activity. Involved in several processes, including negative regulation of epithelial cell proliferation; negative regulation of macromolecule metabolic process; and response to retinoic acid. Predicted to be located in nuclear body; nucleolus; and sex chromatin. Predicted to be part of nucleus; protein-DNA complex; and ribonucleoprotein complex. Biomarker of spina bifida. Human ortholog(s) of this gene implicated in renal Wilms' tumor. Orthologous to human SUZ12 (SUZ12 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 186.3), Thymus (RPKM 161.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q25

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (65464948..65510846)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (64967035..65012916)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (67325101..67371588)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

lncRNA OL1 interacts with Suz12-PRC2 complex to orchestrate the oligodendrocyte differentiation program.
Title: lncRNA Functional Networks in Oligodendrocytes Reveal Stage-Specific Myelination Control by an lncOL1/Suz12 Complex in the CNS.

Submit: New GeneRIF Correction

General gene information

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Markers

RH135952 (e-PCR)
- UniSTS:209948

Suz12 (e-PCR), detects polymorphism
- UniSTS:498256

UniSTS:236667 (e-PCR)
- UniSTS:236667

RH133936 (e-PCR)
- UniSTS:217219

BF395880 (e-PCR)
- UniSTS:245437

BF398270 (e-PCR)
- UniSTS:246729

RH142937 (e-PCR)
- UniSTS:232184

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables enzyme activator activity	ISO Inferred from Sequence Orthology more info
enables lncRNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in facultative heterochromatin formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein modification process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in protein modification process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within random inactivation of X chromosome	ISO Inferred from Sequence Orthology more info
involved_in response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in spinal cord development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of ESC/E(Z) complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESC/E(Z) complex	ISO Inferred from Sequence Orthology more info
part_of RSC-type complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chromatin silencing complex	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-DNA complex	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
located_in sex chromatin	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: polycomb protein SUZ12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427659.1 → NP_001414588.1 polycomb protein SUZ12

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A0G2K2I0, A0A8I6AIG5

Related

ENSRNOP00000093177.1, ENSRNOT00000097306.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

65464948..65510846

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039087645.2 → XP_038943573.1 polycomb protein SUZ12 isoform X1

UniProtKB/TrEMBL

A0A0G2JV08, A0A0G2K2I0

Related

ENSRNOP00000069305.2, ENSRNOT00000085914.3

Conserved Domains (1) summary

pfam09733
Location:522 → 656

VEFS-Box; VEFS-Box of polycomb protein
XM_039087646.2 → XP_038943574.1 polycomb protein SUZ12 isoform X2

UniProtKB/TrEMBL

A6HH95

Conserved Domains (1) summary

pfam09733
Location:248 → 382

VEFS-Box; VEFS-Box of polycomb protein