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    Etfrf1 electron transfer flavoprotein regulatory factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100361188, updated on 9-Dec-2024

    Summary

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    Symbol
    Etfrf1provided by RGD
    Full Name
    electron transfer flavoprotein regulatory factor 1provided by RGD
    Primary source
    RGD:2320673
    See related
    EnsemblRapid:ENSRNOG00000063524 AllianceGenome:RGD:2320673
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lyrm5
    Summary
    Predicted to be involved in respiratory electron transport chain. Predicted to be active in mitochondrion. Orthologous to human ETFRF1 (electron transfer flavoprotein regulatory factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 160.7), Liver (RPKM 123.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Etfrf1 in Genome Data Viewer
    Location:
    4q44
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (179910651..179916095)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (178179814..178188630)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (179476996..179482398)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene branched chain amino acid transaminase 1 Neighboring gene inositol 1,4,5-triphosphate receptor associated 2 Neighboring gene dynein axonemal intermediate chain 7 Neighboring gene uncharacterized LOC134486864 Neighboring gene KRAS proto-oncogene, GTPase Neighboring gene uncharacterized LOC134486865

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. Floyd BJ, et al. Mol Cell, 2016 Aug 18. PMID 27499296, Free PMC Article
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in respiratory electron transport chain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in respiratory electron transport chain ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    electron transfer flavoprotein regulatory factor 1
    Names
    LYR motif containing 5
    LYR motif-containing protein 5
    ghiso

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399056.1 → NP_001385985.1  electron transfer flavoprotein regulatory factor 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IMZ9, D4AD58
      Related
      ENSRNOP00000078423.1, ENSRNOT00000101701.2
      Conserved Domains (1) summary
      cd20265
      Location:6 → 79
      Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins

    2. NM_001399057.1 → NP_001385986.1  electron transfer flavoprotein regulatory factor 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IMZ9, D4AD58
      Conserved Domains (1) summary
      cd20265
      Location:6 → 79
      Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      179910651..179916095
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237673.5 → XP_006237735.1  electron transfer flavoprotein regulatory factor 1 isoform X1

      See identical proteins and their annotated locations for XP_006237735.1

      UniProtKB/TrEMBL
      A6IMZ9, D4AD58
      Conserved Domains (1) summary
      cd20265
      Location:6 → 79
      Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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